Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.62 |
| ▸ | NPC1 | O15118 | 10/20 | 0.62 |
| ▸ | GAA | P10253 | 8/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 7/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MITF | O75030 | 2/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | KDM5C | P41229 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2904195 | 0.83 | ALDH1A1 (0.46) | RAB9AALDH1A1KDM4ENPC1GAA | |
| SCHEMBL3671369 | 0.82 | ALDH1A1 (0.62) | RAB9AALDH1A1KDM4ENPC1GAA | |
| SCHEMBL9560121 | 0.82 | DYRK1A (0.50) | RAB9AALDH1A1KDM4ENPC1GAA | |
| SCHEMBL17626904 | 0.81 | KMO (0.47) | RAB9AALDH1A1KDM4ENPC1GAA | |
| SCHEMBL17626882 | 0.77 | ALDH1A1 (1.00) | RAB9AALDH1A1KDM4ENPC1GAA | |
| SCHEMBL17626896 | 0.76 | JAK2 (0.40) | RAB9AALDH1A1KDM4ENPC1GAA | |
| SCHEMBL26146239 | 0.74 | MKNK1 (0.43) | MAPT | |
| SCHEMBL6102107 | 0.74 | ALDH1A1 (0.39) | RAB9AALDH1A1KDM4ENPC1GAA | |
| SCHEMBL6221104 | 0.71 | ACHE (0.38) | RAB9AALDH1A1KDM4ENPC1GAA | |
| SCHEMBL1829674 | 0.71 | KMO (0.47) | RAB9AALDH1A1KDM4ENPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2999701-A1 | 2-PHENYLIMIDAZO[1,2-A]PYRIMIDINES AS IMAGING AGENTS | Hoffmann-La Roche Inc. (US) | 2016-03-30 | — | — | EP | disclosed |