SCHEMBL17632480

SCHEMBL17632480

COCC1(C(=O)Nc2ncc(-c3ccccc3)s2)CCN(C(=O)OC(C)(C)C)C1

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ OTUD7B Q6GQQ9 5/20 0.47
▸ MKNK1 Q9BUB5 1/20 0.46
▸ USP30 Q70CQ3 5/20 0.46
▸ NPY5R Q15761 2/20 0.45
▸ SCD5 Q86SK9 1/20 0.43
▸ FFAR2 O15552 1/20 0.42
▸ KDR P35968 1/20 0.42
▸ CCNE1 P24864 1/20 0.41
▸ CDK2 P24941 1/20 0.41
▸ CDK5 Q00535 1/20 0.41
▸ ACP1 P24666 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19031372 0.85 OTUD7B (0.64) OTUD7BMKNK1USP30NPY5RSCD5
SCHEMBL25052373 0.82 OTUD7B (0.68) OTUD7BMKNK1USP30
SCHEMBL17632243 0.82 OTUD7B (0.68) OTUD7BMKNK1USP30
SCHEMBL17632028 0.77 OTUD7B (0.61) OTUD7BMKNK1USP30
SCHEMBL5349433 0.76 CNR2 (0.62) MKNK1USP30NPY5RFFAR2KDR
SCHEMBL28497363 0.74 MKNK1 (0.67) MKNK1USP30
SCHEMBL19296045 0.74 MKNK1 (0.67) MKNK1USP30
SCHEMBL14240433 0.73 KDR (0.45) MKNK1USP30NPY5RKDR
SCHEMBL28014843 0.72 KDR (0.62) MKNK1USP30FFAR2KDRCCNE1
SCHEMBL14240667 0.72 KDR (0.43) MKNK1USP30NPY5RKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11993595-B2 Compounds MISSION THERAPEUTICS LIMITED (GB) 2024-05-28 — — US disclosed
CN-111592534-B New compounds 特殊治疗有限公司 2023-06-30 — — CN disclosed
US-20230052191-A1 NOVEL COMPOUNDS MISSION THERAPEUTICS LTD (GB) 2023-02-16 — — US disclosed
US-11472798-B2 Compounds MISSION THERAPEUTICS LTD (GB) 2022-10-18 — — US disclosed
EP-3828179-A1 CYANOPYRROLIDINES AS DUB MODULATORS Mission Therapeutics Limited (GB) 2021-06-02 — — EP disclosed
US-20200369658-A1 NOVEL COMPOUNDS MISSION THERAPEUTICS LTD (GB) 2020-11-26 — — US disclosed
US-10774078-B2 Compounds MISSION THERAPEUTICS LTD (GB) 2020-09-15 — — US disclosed
CN-111592534-A Novel compounds 特殊治疗有限公司 2020-08-28 — — CN disclosed
EP-3197883-B1 NOVEL COMPOUNDS MISSION THERAPEUTICS LTD (GB) 2020-03-18 — — EP disclosed
CN-107001339-B Novel compounds 特殊治疗有限公司 2020-03-17 — — CN disclosed
US-20190330202-A1 NOVEL COMPOUNDS MISSION THERAPEUTICS LTD (GB) 2019-10-31 — — US disclosed
US-10392380-B2 Compounds MISSION THERAPEUTICS LIMITED (GB) 2019-08-27 — — US disclosed
US-20180162852-A1 NOVEL COMPOUNDS MISSION THERAPEUTICS LIMITED 2018-06-14 — — US disclosed
US-9926307-B2 Compounds MISSION THERAPEUTICS LTD (GB) 2018-03-27 — — US disclosed
US-20170247365-A1 NOVEL COMPOUNDS MISSION THERAPEUTICS LTD (GB) 2017-08-31 — — US disclosed
EP-3197883-A1 NOVEL COMPOUNDS Mission Therapeutics Limited (GB) 2017-08-02 — — EP disclosed
WO-2016046530-A1 NOVEL COMPOUNDS MISSION THERAPEUTICS LTD (GB) 2016-03-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10774078-B2 Compounds UCHL1, UCHL3, UCHL5 OTUD7B 57/4885MKNK1 2009/4885USP30 20/4885
US-11472798-B2 Compounds UCHL1, UCHL3, UCHL5 OTUD7B 57/4885MKNK1 2009/4885USP30 20/4885
US-20180162852-A1 NOVEL COMPOUNDS UCHL1, UCHL3, UCHL5 OTUD7B 64/4885MKNK1 2081/4885USP30 19/4885
US-10392380-B2 Compounds UCHL1, UCHL3, UCHL5 OTUD7B 57/4885MKNK1 2009/4885USP30 20/4885
US-11993595-B2 Compounds UCHL1, UCHL3, UCHL5 OTUD7B 57/4885MKNK1 2009/4885USP30 20/4885
US-20200369658-A1 NOVEL COMPOUNDS UCHL1, UCHL3, UCHL5 OTUD7B 64/4885MKNK1 2081/4885USP30 19/4885
US-20190330202-A1 NOVEL COMPOUNDS UCHL1, UCHL3, UCHL5 OTUD7B 64/4885MKNK1 2081/4885USP30 19/4885
US-20170247365-A1 NOVEL COMPOUNDS UCHL1, UCHL3, UCHL5 OTUD7B 64/4885MKNK1 2081/4885USP30 19/4885
US-20230052191-A1 NOVEL COMPOUNDS UCHL1, UCHL3, UCHL5 OTUD7B 64/4885MKNK1 2081/4885USP30 19/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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