Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxribtimine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | TK2 | O00142 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | ALB | P02768 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxribtimine SCHEMBL8075845 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL887722 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL77830 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL21682515 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL9687292 | 0.99 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL29150139 | 0.98 | TK1 (0.65) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL7576317 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL5692278 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL9386574 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL9385913 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3066 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098284-A1 | CELL-FREE PPi-DRIVEN ATP REGENERATION PLATFORM | TYMOSHENKO STEPAN (US) | 2026-04-09 | — | — | US | claimed |
| EP-4716745-A1 | NEW TLR-4 ANTAGONIST APTAMERS | Merck Patent GmbH (DE) | 2026-04-01 | — | — | EP | claimed |
| EP-3931346-B1 | USING TETHERED ENZYMES TO DETECT NUCLEIC ACIDS | UNIV CORNELL (US) | 2026-02-25 | — | — | EP | claimed |
| CN-120064427-A | Method and analysis system for detecting brain nucleic acid hydrolysate spatial distribution based on mass spectrum imaging | 北京脑科学与类脑研究所 | 2025-05-30 | — | — | CN | claimed |
| WO-2024240750-A1 | NEW TLR-4 ANTAGONIST APTAMERS | APTATARGETS, S.L. (ES) | 2024-11-28 | — | — | WO | claimed |
| WO-2024216536-A1 | METHOD FOR PREPARING RIBONUCLEOSIDE OR DERIVATIVE THEREOF, AND BIOLOGICAL ENZYME PREPARATION AND APPLICATION THEREOF | 百瑞全球有限公司 | 2024-10-24 | — | — | WO | claimed |
| CN-116115769-B | Nucleoside phosphate protein intracellular delivery system and preparation method and application thereof | 苏州大学 | 2024-09-06 | — | — | CN | claimed |
| EP-4403042-A2 | FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME | Mars, Incorporated (US) | 2024-07-24 | — | — | EP | claimed |
| EP-3229612-B1 | USE OF FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME | MARS INC (US) | 2024-06-26 | — | — | EP | claimed |
| CN-116463120-B | Room-temperature circularly polarized phosphorescent material based on carbon quantum dot-nucleobase derivative and preparation method thereof | 上海大学 | 2024-04-09 | — | — | CN | claimed |
| US-6245506-B1 | IMMOBILIZING BIOPOLYMER ON SOLID SUPPORT IN REACTION VESSEL, MIXING WITH ION DEPENDENT ENZYME AND PRESSURE SENSITIVE BUFFER, ALTERING PRESSURE IN THE VESSEL TO ALLOW REACTION TO OCCUR, DETERMINING IDENTITY OF DISSOCIATED TERMINAL MONOMER | BBI BIOSEQ, INC. | 2001-06-12 | — | — | US | claimed |
| WO-2001008691-A1 | METHODS FOR TRANSDIFFERENTIATION OF BODY TISSUES | BARANOWITZ STEVEN (US) | 2001-02-08 | — | — | WO | claimed |
| US-5891452-A | Cosmetic or dermatological composition containing at least one active principle precursor and a crosslinked poly(2-acrylamido-2-methylpropanesulphonic acid) polymer neutralized to at least 90% | L'OREAL (FR) | 1999-04-06 | — | — | US | claimed |
| EP-0504279-B1 | FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES | CHEMGEN CORP (US) | 1997-07-09 | — | — | EP | claimed |
| WO-1995012687-A1 | IN SITU MEASUREMENT OF BACTERIAL GROWTH IN WASTEWATER TREATMENT PROCESSES | CRC FOR WASTE MANAGEMENT AND POLLUTION CONTROL LIMITED (AU) | 1995-05-11 | — | — | WO | claimed |
| EP-0360641-B1 | DNA sequence participating in the regulation of the expression of a DNA sequence encoding a polypeptide precursor, expression vectors, and method for the periplasmic production of the polypeptide | SANOFI SA (FR) | 1994-11-30 | — | — | EP | claimed |
| US-5213972-A | Production of thymidine and deoxyuridine, intermediates for AZT | CHEMGEN CORPORATION (US) | 1993-05-25 | — | — | US | claimed |
| EP-0504279-A4 | FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES | — | 1993-02-17 | — | — | EP | claimed |
| EP-0504279-A1 | FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES. | CHEMGEN CORP (US) | 1992-09-23 | — | — | EP | claimed |
| WO-1991009130-A1 | FERMENTATION PROCESS FOR THE PRODUCTION OF PYRIMIDINE DEOXYRIBONUCLEOSIDES | CHEMGEN CORPORATION (US) | 1991-06-27 | — | — | WO | claimed |