Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxribtimine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | TK2 | O00142 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | ALB | P02768 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxribtimine SCHEMBL8075845 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL77830 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL176363 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL21682515 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL9687292 | 0.99 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL29150139 | 0.98 | TK1 (0.65) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL7576317 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL5692278 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL9386574 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL9385913 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058031-B2 | Labeled nucleotide analogs and uses therefor | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2011-11-15 | — | — | US | disclosed |
| US-20110059450-A1 | LABELED NUCLEOTIDE ANALOGS AND USES THEREFOR | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2011-03-10 | — | — | US | disclosed |
| US-7777013-B2 | Labeled nucleotide analogs and uses therefor | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20090018324-A1 | LABELED NUCLEOTIDE ANALOGS AND USES THEREFOR | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2009-01-15 | — | — | US | disclosed |
| US-7405281-B2 | Fluorescent nucleotide analogs and uses therefor | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2008-07-29 | — | — | US | disclosed |
| EP-1937702-A2 | LABELED NUCLEOTIDE ANALOGS AND USES THEREFOR | Pacific Biosciences of California, Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007041342-A2 | LABELED NUCLEOTIDE ANALOGS AND USES THEREFOR | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20070072196-A1 | Fluorescent nucleotide analogs and uses therefor | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072196-A1 | Fluorescent nucleotide analogs and uses therefor | DNTT, POLRMT, RNGTT | TK1 29/4885LMNA 1033/4885SMN1; SMN2 3743/4885 |
| US-20090018324-A1 | LABELED NUCLEOTIDE ANALOGS AND USES THEREFOR | POLRMT, DNTT, NUDT1 | TK1 12/4885LMNA 1292/4885SMN1; SMN2 3838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.