Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxribtimine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | TK2 | O00142 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | ALB | P02768 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxribtimine SCHEMBL8075845 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL887722 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL176363 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL21682515 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL9687292 | 0.99 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL29150139 | 0.98 | TK1 (0.65) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL7576317 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL5692278 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL9386574 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL9385913 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4035 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12630469-B2 | Method for producing structured glass articles by alkaline etching | SCHOTT AG (DE) | 2026-05-19 | — | — | US | claimed |
| EP-4729633-A2 | METHODS FOR DETECTING NUCLEIC ACID VARIANTS | Guardant Health, Inc. (US) | 2026-04-22 | — | — | EP | claimed |
| EP-4291679-B1 | METHODS FOR DETECTING NUCLEIC ACID VARIANTS | GUARDANT HEALTH INC (US) | 2026-02-04 | — | — | EP | claimed |
| EP-4682514-A1 | METHOD FOR ANALYZING CELLS AND CELL-RELATED MATERIALS, AND SYSTEM | Live Cell Diagnosis, Ltd. (JP) | 2026-01-21 | — | — | EP | claimed |
| EP-4605523-A1 | OLIGONUCLEOTIDES AND METHODS FOR CAPTURING SINGLE-STRANDED TEMPLATES AND/OR TEMPLATES WITH 3' OVERHANGS | Foundation Medicine, Inc. (US) | 2025-08-27 | — | — | EP | claimed |
| CN-120064427-A | Method and analysis system for detecting brain nucleic acid hydrolysate spatial distribution based on mass spectrum imaging | 北京脑科学与类脑研究所 | 2025-05-30 | — | — | CN | claimed |
| WO-2024216536-A1 | METHOD FOR PREPARING RIBONUCLEOSIDE OR DERIVATIVE THEREOF, AND BIOLOGICAL ENZYME PREPARATION AND APPLICATION THEREOF | 百瑞全球有限公司 | 2024-10-24 | — | — | WO | claimed |
| WO-2024172082-A1 | METHOD FOR ANALYZING CELLS AND CELL-RELATED MATERIALS, AND SYSTEM | 株式会社ライブセルダイアグノシス | 2024-08-22 | — | — | WO | claimed |
| EP-4409024-A1 | COMPOSITIONS AND METHODS FOR SYNTHESIS AND USE OF PROBES TARGETING NUCLEIC ACID REARRANGEMENTS | Guardant Health, Inc. (US) | 2024-08-07 | — | — | EP | claimed |
| EP-4403042-A2 | FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME | Mars, Incorporated (US) | 2024-07-24 | — | — | EP | claimed |
| WO-1997042348-A1 | PROCESS FOR DIRECT SEQUENCING DURING TEMPLATE AMPLIFICATION | SEQUENOM, INC. (US) | 1997-11-13 | — | — | WO | claimed |
| WO-1997032999-A1 | SIMULTANEOUS SEQUENCING OF TAGGED POLYNUCLEOTIDES | LYNX THERAPEUTICS, INC. (US) | 1997-09-12 | — | — | WO | claimed |
| EP-0695366-A1 | METHOD OF RANDOM AMPLIFICATION OF POLYMORPHIC DNA | F B Investments Pty. Ltd. (AU) | 1996-02-07 | — | — | EP | claimed |
| US-5437978-A | Nucleotide fragments as primers for polymerase chain reaction used in detection of toxic shock or methicillin-resistant bacteria, kits | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1995-08-01 | — | — | US | claimed |
| WO-1994024307-A1 | METHOD OF RANDOM AMPLIFICATION OF POLYMORPHIC DNA | FORBIO PTY. LTD. (AU) | 1994-10-27 | — | — | WO | claimed |
| US-5132291-A | 3'-Azido-3'deoxy-thymidine administering with a purine compound | GENSIA PHARMACEUTICALS, INC. (US) | 1992-07-21 | — | — | US | claimed |
| EP-0406408-A4 | ANTIVIRALS AND METHODS FOR INCREASING THE ANTIVIRAL ACTIVITY OF AZT | — | 1992-01-02 | — | — | EP | claimed |
| EP-0406408-A1 | ANTIVIRALS AND METHODS FOR INCREASING THE ANTIVIRAL ACTIVITY OF AZT | GENSIA, INC. (US) | 1991-01-09 | — | — | EP | claimed |
| WO-1990008550-A1 | ANTIVIRALS AND METHODS FOR INCREASING THE ANTIVIRAL ACTIVITY OF AZT | GENSIA PHARMACEUTICALS, INC. (US) | 1990-08-09 | — | — | WO | claimed |
| EP-0343955-A2 | Process for complex binding of targeted molecular species | BIOVENTURES, INC. (US) | 1989-11-29 | — | — | EP | claimed |