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Doxribtimine

Doxribtimine

SCHEMBL7576317

CP(=O)(O)O.Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O.Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O.Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O.Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O.Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O.Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O.Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O.Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

P

The experimentally established mechanism targets of Doxribtimine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ TK1 P04183 4/20 0.66
▸ LMNA P02545 3/20 0.66
▸ SMN1; SMN2 Q16637 1/20 0.66
▸ POLB P06746 1/20 0.66
▸ TK2 O00142 1/20 0.64
▸ TSHR P16473 2/20 0.64
▸ ALB P02768 1/20 0.64
▸ PKM P14618 1/20 0.64
▸ BLM P54132 1/20 0.64
▸ PMP22 Q01453 1/20 0.64
▸ CYP2D6 P10635 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Doxribtimine SCHEMBL5692278 1.00 TK1 (0.66) TK1LMNASMN1; SMN2POLBTK2
Doxribtimine SCHEMBL9386574 1.00 TK1 (0.66) TK1LMNASMN1; SMN2POLBTK2
Doxribtimine SCHEMBL9385913 1.00 TK1 (0.66) TK1LMNASMN1; SMN2POLBTK2
Doxribtimine SCHEMBL887722 0.97 TK1 (0.67) TK1LMNASMN1; SMN2POLBTK2
Doxribtimine SCHEMBL176363 0.97 TK1 (0.67) TK1LMNASMN1; SMN2POLBTK2
Doxribtimine SCHEMBL21682515 0.97 TK1 (0.67) TK1LMNASMN1; SMN2POLBTK2
Doxribtimine SCHEMBL77830 0.97 TK1 (0.67) TK1LMNASMN1; SMN2POLBTK2
Doxribtimine SCHEMBL8075845 0.97 TK1 (0.67) TK1LMNASMN1; SMN2POLBTK2
Doxribtimine SCHEMBL9687292 0.95 TK1 (0.66) TK1LMNASMN1; SMN2POLBTK2
Doxribtimine SCHEMBL8217370 0.94 TK1 (0.65) TK1LMNASMN1; SMN2POLBTK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024040041-A1 REGULATION OF ACTIVITY OF RNAI MOLECULES DICERNA PHARMACEUTICALS, INC. (US) 2024-02-22 — — WO disclosed
WO-2023081500-A2 RNAi OLIGONUCLEOTIDE CONJUGATES DICERNA PHARMACEUTICALS, INC. (US) 2023-05-11 — — WO disclosed
EP-0850248-B1 COMPOSITIONS AND METHODS FOR THE SYNTHESIS OF ORGANOPHOSPHORUS DERIVATIVES POLSKA AKAD NAUK CENTRUM (PL) 2002-07-24 — — EP disclosed
US-6028188-A Synthetic oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages GENTA INCORPORATED (US) 2000-02-22 — — US disclosed
US-5955597-A NUCLEOSIDES WHICH HYBRIDIZE TO RNA TARGET SEQUENCES, DIMERS, TRIMERS OR TETRAMERS GENTA, INCORPORATED (US) 1999-09-21 — — US disclosed
US-5856465-A NUCLEOSIDE INTERMEDIATES POLSKA AKADEMIA NAUK CENTRUM BADAN MOLEKULARNYCH I MAKROMOLEKULARNYCH (PL) 1999-01-05 — — US disclosed
US-5837856-A Chirally enriched synthetic phosphonate oligomers GENTA, INCORPORATED (US) 1998-11-17 — — US disclosed
EP-0729474-A4 SYNTHETIC OLIGOMERS HAVING CHIRALLY PURE PHOSPHONATE INTERNUCLEOSIDYL LINKAGES MIXED WITH NON-PHOSPHONATE INTERNUCLEOSIDYL LINKAGES GENTA INC (US) 1998-10-21 — — EP disclosed
US-5792615-A ANTISENSE NUCLEOTIDES PREVENTING OR INTERFERING THE GENE EXPRESSION OR TRANSLATION OF SINGLE-STRANDED RNA GENTA, INCORPORATED (US) 1998-08-11 — — US disclosed
EP-0850248-A1 COMPOSITIONS AND METHODS FOR THE SYNTHESIS OF ORGANOPHOSPHORUS DERIVATIVES POLSKA AKADEMIA NAUK CENTRUM BADAN MOLEKULARNYCH I MAKROMOLEKULARNYCH (PL) 1998-07-01 — — EP disclosed
WO-1997009340-A1 COMPOSITIONS AND METHODS FOR THE SYNTHESIS OF ORGANOPHOSPHORUS DERIVATIVES POLSKA AKADEMIA NAUK CENTRUM BADAN MOLEKULARNYCH I MAKROMOLEKULARNYCH (PL) 1997-03-13 — — WO disclosed
EP-0731809-A1 CHIRALLY ENRICHED SYNTHETIC PHOSPHONATE OLIGOMERS GENTA INCORPORATED (US) 1996-09-18 — — EP disclosed
EP-0729474-A1 SYNTHETIC OLIGOMERS HAVING CHIRALLY PURE PHOSPHONATE INTERNUCLEOSIDYL LINKAGES MIXED WITH NON-PHOSPHONATE INTERNUCLEOSIDYL LINKAGES GENTA INCORPORATED (US) 1996-09-04 — — EP disclosed
WO-1995014030-A1 SYNTHETIC OLIGOMERS HAVING CHIRALLY PURE PHOSPHONATE INTERNUCLEOSIDYL LINKAGES MIXED WITH NON-PHOSPHONATE INTERNUCLEOSIDYL LINKAGES GENTA INCORPORATED (US) 1995-05-26 — — WO disclosed
WO-1995014031-A1 CHIRALLY ENRICHED SYNTHETIC PHOSPHONATE OLIGOMERS GENTA INCORPORATED (US) 1995-05-26 — — WO disclosed