Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxribtimine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | TK2 | O00142 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | ALB | P02768 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxribtimine SCHEMBL887722 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL77830 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL176363 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL21682515 | 1.00 | TK1 (0.67) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL9687292 | 0.99 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL29150139 | 0.98 | TK1 (0.65) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL7576317 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL5692278 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL9386574 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 | |
| Doxribtimine SCHEMBL9385913 | 0.97 | TK1 (0.66) | TK1LMNASMN1; SMN2POLBTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4146280-A1 | LINKER COMPOUNDS | Mpeg LA, L.l.c. (US) | 2023-03-15 | — | — | EP | disclosed |
| CN-115515968-A | Allele-specific silencing of transforming growth factor beta-inducible genes with R124H mutation using short interfering RNA | 阿维利诺美国实验室股份有限公司 | 2022-12-23 | — | — | CN | disclosed |
| US-6124445-A | PRO DRUGS FOR OLIGONUCLEOTIDES HAVING BIOREVERSIBLE PHOSPHATE BLOCKING GROUPS | ISIS PHARMACEUTICALS, INC. (US) | 2000-09-26 | — | — | US | disclosed |
| US-5955591-A | OLIGONUCLEOTIDES HAVING BIOREVERSIBLE PHOSPHATE BLOCKING GROUPS; USED AS PRODRUGS; ANTISENSE AGENTS | CENTER NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 1999-09-21 | — | — | US | disclosed |
| EP-0912592-A1 | PHOSPHOTRIESTER OLIGONUCLEOTIDES, AMIDITES AND METHOD OF PREPARATION | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1999-05-06 | — | — | EP | disclosed |
| US-5750666-A | FOR SYNTHESIZING NEW MONONUCLEOTIDES AND POLYNUCLEOTIDES HAVING PHOSPHOROTHIOATE AND PHOSPHORODITHIOATE INTERNUCLEOTIDE LINKAGES | COMPETITVE TECHNOLOGIES, INC. (US) | 1998-05-12 | — | — | US | disclosed |
| WO-1997047637-A1 | PHOSPHOTRIESTER OLIGONUCLEOTIDES, AMIDITES AND METHOD OF PREPARATION | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (US) | 1997-12-18 | — | — | WO | disclosed |
| US-5684148-A | NUCLEOSIDES AND POLYNUCLEOTIDES AS FLUORESCENT AGENTS FOR MEDICAL DIAGNOSIS | COMPETITIVE TECHNOLOGIES, INC. (US) | 1997-11-04 | — | — | US | disclosed |
| US-5637683-A | REACTING AN AMINE HAVING BASE SELECTED FROM URACIL, ADENINE, GUANINE, CYTOSINE, THYMINE, OR HYPOXANTHINE, WITH PENTAFLUOROPHENYL ESTER DERIVATIVE TO FORM INTERMEDIATE, REACTING INTERMEDIATE WITH ADDITIONAL AMINE | CORNELL RESEARCH FOUNDATION, INC. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5602244-A | DINUCLEOSIDE PRECURSORS IN OLIGONUCLEOTIDE SYNTHESIS; USEFUL AS ANTISENSE INHIBITORS OF TRANSLATION | COMPETITIVE TECHNOLOGIES, INC. (US) | 1997-02-11 | — | — | US | disclosed |
| US-5548076-A | CONDENSING A BLOCKED NUCLEOSIDE BOUND TO A CARRIER | GENENTECH, INC. (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0219342-B1 | Method and reagents for in vitro oligonucleotide synthesis | GENENTECH INC (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5264566-A | Method for in vitro oligonucleotide synthesis using H-phosphonates | GENENTECH, INC. (US) | 1993-11-23 | — | — | US | disclosed |
| US-5218103-A | Nucleoside thiophosphoramidites | UNIVERSITY PATENTS, INC. (US) | 1993-06-08 | — | — | US | disclosed |
| EP-0378615-A4 | NUCLEOSIDE AND POLYNUCLEOTIDE THIOPHOSPHORAMIDITE AND PHOSPHORODITHIOATE COMPOUNDS AND PROCESSES | — | 1992-04-08 | — | — | EP | disclosed |
| WO-1991004983-A1 | NUCLEOSIDE AND POLYNUCLEOTIDE THIOPHOSPHORAMIDITE AND PHOSPHORODITHIOATE COMPOUNDS AND PROCESSES | UNIVERSITY PATENTS, INC. (US) | 1991-04-18 | — | — | WO | disclosed |
| US-4959463-A | Intermediates | GENENTECH, INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0378615-A1 | NUCLEOSIDE AND POLYNUCLEOTIDE THIOPHOSPHORAMIDITE AND PHOSPHORODITHIOATE COMPOUNDS AND PROCESSES | COMPETITIVE TECHNOLOGIES INC. (US) | 1990-07-25 | — | — | EP | disclosed |
| WO-1989011486-A1 | NUCLEOSIDE AND POLYNUCLEOTIDE THIOPHOSPHORAMIDITE AND PHOSPHORODITHIOATE COMPOUNDS AND PROCESSES | UNIVERSITY PATENTS, INC. (US) | 1989-11-30 | — | — | WO | disclosed |
| EP-0219342-A2 | Method and reagents for in vitro oligonucleotide synthesis | GENENTECH, INC. (US) | 1987-04-22 | — | — | EP | disclosed |