Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.73 |
| ▸ | GAA | P10253 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | THRB | P10828 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27633763 | 0.93 | MAPT (0.73) | MAPTGAAKDM4ETHRBNPC1 | |
| SCHEMBL1006629 | 0.87 | ALDH1A1 (0.54) | MAPTGAAKDM4ETHRBNPC1 | |
| SCHEMBL28040243 | 0.84 | MAPT (0.53) | MAPTGAAKDM4ETHRBNPC1 | |
| SCHEMBL16192920 | 0.82 | NOX1 (0.56) | MAPTGAAKDM4ETHRBNPC1 | |
| SCHEMBL17637667 | 0.81 | RAB9A (0.59) | MAPTGAAKDM4ETHRBNPC1 | |
| SCHEMBL17637668 | 0.80 | MAPT (0.69) | MAPTGAAKDM4ETHRBNPC1 | |
| SCHEMBL17416148 | 0.79 | MAPT (0.50) | MAPTGAAKDM4ETHRBNPC1 | |
| SCHEMBL16193004 | 0.79 | KDM4E (0.68) | MAPTGAAKDM4ETHRBNPC1 | |
| SCHEMBL6037499 | 0.79 | ALDH1A1 (0.75) | MAPTGAAKDM4ETHRBNPC1 | |
| SCHEMBL27633944 | 0.79 | CYP1A2 (0.69) | MAPTGAAKDM4ETHRBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160090351-A1 | INHIBITORS OF DEUBIQUITINATING PROTEASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160090351-A1 | INHIBITORS OF DEUBIQUITINATING PROTEASES | USP1, USP2, USP18 | MAPT 2639/4885GAA 328/4885KDM4E 1307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.