Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16192972 | 0.85 | CA2 (0.48) | CA2ALDH1A1TSHRHTR2APTGS2 | |
| SCHEMBL6897012 | 0.84 | THRB (0.51) | CA2ALDH1A1RAB9APTGS2SMN1; SMN2 | |
| SCHEMBL1788228 | 0.82 | RAB9A (0.50) | CA2ALDH1A1TSHRRAB9ARXRA | |
| SCHEMBL6896573 | 0.82 | THRB (0.57) | ALDH1A1PPARAPTGS2 | |
| SCHEMBL6894515 | 0.82 | THRB (0.57) | ALDH1A1PPARAPTGS2 | |
| SCHEMBL12117284 | 0.82 | THRB (0.57) | ALDH1A1PPARAPTGS2 | |
| SCHEMBL47952 | 0.82 | RAB9A (0.56) | ALDH1A1RAB9APPARGPPARARXRA | |
| SCHEMBL11170817 | 0.81 | SMN1; SMN2 (0.50) | CA2ALDH1A1TSHRRAB9ARXRA | |
| SCHEMBL1791187 | 0.81 | CA2 (0.47) | CA2ALDH1A1TSHRHTR2A | |
| SCHEMBL1790169 | 0.81 | ALDH1A1 (0.55) | CA2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160090351-A1 | INHIBITORS OF DEUBIQUITINATING PROTEASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160090351-A1 | INHIBITORS OF DEUBIQUITINATING PROTEASES | USP1, USP2, USP18 | CA2 3999/4885ALDH1A1 3224/4885TSHR 3966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.