SCHEMBL1765929

SCHEMBL1765929

CC(=O)Nc1cc(I)cc(NC(C)=O)n1

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.52
ADORA3 P0DMS8 17/20 0.50
ADORA2A P29274 4/20 0.50
ADORA1 P30542 2/20 0.50
ADORA2B P29275 2/20 0.46
MAPK8 P45983 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26686474 0.88 ADORA3 (0.50) L3MBTL1ADORA3ADORA2AADORA1ADORA2B
SCHEMBL30515308 0.87 ADORA3 (0.49) L3MBTL1ADORA3ADORA2AADORA1ADORA2B
SCHEMBL4552644 0.80 LMNA (0.56) L3MBTL1ADORA3ADORA2AADORA1ADORA2B
SCHEMBL18658437 0.80 ADORA3 (0.54) L3MBTL1ADORA3ADORA2AADORA1ADORA2B
SCHEMBL1766001 0.78 L3MBTL1 (0.52) L3MBTL1ADORA3ADORA2AADORA1ADORA2B
SCHEMBL12975420 0.76 L3MBTL1 (0.55) L3MBTL1
SCHEMBL4552543 0.76 L3MBTL1 (0.59) L3MBTL1ADORA3ADORA2AADORA1ADORA2B
SCHEMBL23274769 0.75 ADORA2A (0.59) ADORA2AADORA1
SCHEMBL29762385 0.75 ADORA2A (0.59) ADORA2AADORA1
SCHEMBL21728888 0.75 L3MBTL1 (0.48) L3MBTL1ADORA3ADORA2AADORA1ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10442771-B2 Trans-base tunnel reader for sequencing ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-10-15 US disclosed
US-20170204066-A1 NANOPORE BASED SEQUENCER ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2017-07-20 US disclosed
US-9593372-B2 Nanopore based sequencer ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2017-03-14 US disclosed
US-20150211059-A1 TRANS-BASE TUNNEL READER FOR SEQUENCING ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2015-07-30 US disclosed
US-8968540-B2 Trans-base tunnel reader for sequencing ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2015-03-03 US disclosed
US-8961757-B2 Nanopore and carbon nanotube based DNA sequencer ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2015-02-24 US disclosed
US-20130186757-A1 Nanopore and Carbon Nanotube Based Dna Sequencer and A Serial Recognition Elements ARIZONA BOARD OF REGENTS (US) 2013-07-25 US disclosed
US-20110168562-A1 Nanopore and Carbon Nanotube Based DNA Sequencer ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY 2011-07-14 US disclosed
US-20110120868-A1 Nanopore and Carbon Nanotube Based DNA Sequencer and a Serial Recognition Sequencer ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2011-05-26 US disclosed
WO-2010042514-A1 NANOPORE AND CARBON NANOTUBE BASED DNA SEQUENCER AND A SERIAL RECOGNITION ELEMENTS ARIZONA BOARD OF REGENTS (US) 2010-04-15 WO disclosed
WO-2009117522-A2 NANOPORE AND CARBON NANOTUBE BASED DNA SEQUENCER AND A SERIAL RECOGNITION SEQUENCER REINHART, KEVIN (US) 2009-09-24 WO disclosed
WO-2009117517-A2 NANOPORE AND CARBON NANOTUBE BASED DNA SEQUENCER ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2009-09-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170204066-A1 NANOPORE BASED SEQUENCER DNMT3A, DNTT, TELO2 L3MBTL1 2596/4885ADORA3 3857/4885ADORA2A 4336/4885
US-10442771-B2 Trans-base tunnel reader for sequencing DNTT, TRDMT1, TELO2 L3MBTL1 1043/4885ADORA3 1700/4885ADORA2A 2173/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.