Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10359523 | 0.91 | ALDH1A1 (0.39) | MAPTGAARAB9AALDH1A1MEN1 | |
| SCHEMBL10360042 | 0.90 | RAB9A (0.38) | MAPTGAARAB9AALDH1A1 | |
| SCHEMBL22111686 | 0.86 | MAPT (0.47) | MAPTGAARAB9AALDH1A1HPGD | |
| SCHEMBL11161272 | 0.83 | ALDH1A1 (0.46) | MAPTGAAALDH1A1HPGDAKR1C1 | |
| SCHEMBL12648133 | 0.83 | MAP1LC3B (0.44) | LMNAPOLBMAP1LC3B | |
| SCHEMBL11170815 | 0.82 | MAPT (0.50) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL12648266 | 0.81 | ALDH1A1 (0.46) | MAPTGAARAB9AALDH1A1HPGD | |
| SCHEMBL12648386 | 0.81 | MAPT (0.53) | MAPTGAARAB9AALDH1A1HPGD | |
| SCHEMBL11163428 | 0.81 | GAA (0.47) | MAPTGAAALDH1A1HPGDAKR1C1 | |
| SCHEMBL11164822 | 0.81 | SMN1; SMN2 (0.45) | MAPTGAARAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846747-B2 | Compounds and methods for altering lifespan of eukaryotic organisms | UNIVERSITY OF ROCHESTER (US) | 2014-09-30 | — | — | US | disclosed |
| US-20130096175-A1 | Compounds and Methods for Altering Lifespan of Eukaryotic Organisms | SOUTHERN RESEARCH INSTITUTE (US) | 2013-04-18 | — | — | US | disclosed |
| EP-2501229-A1 | COMPOUNDS AND METHODS FOR ALTERING LIFESPAN OF EUKARYOTIC ORGANISMS | University Of Rochester (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011062964-A1 | COMPOUNDS AND METHODS FOR ALTERING LIFESPAN OF EUKARYOTIC ORGANISMS | UNIVERSITY OF ROCHESTER (US) | 2011-05-26 | — | — | WO | disclosed |
| EP-0202042-B1 | CYCLOHEXANE-1,3-DIONE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PROCESSES FOR PREPARING THEM, AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS | ICI AUSTRALIA LIMITED (AU) | 1990-05-09 | — | — | EP | disclosed |
| US-4746350-A | Herbicidal bis(cyclohexane-1,3-dione)derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096175-A1 | Compounds and Methods for Altering Lifespan of Eukaryotic Organisms | HDAC5, AADAC, SIRT1 | MAPT 2167/4885GAA 1628/4885RAB9A 4484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.