Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
| ▸ | LEF1 | Q9UJU2 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16396248 | 0.82 | HDAC1 (0.48) | CA12CA1CA9PSMB8LEF1 | |
| SCHEMBL29469370 | 0.81 | MGLL (0.39) | MGLL | |
| SCHEMBL16395811 | 0.78 | PTPN2 (0.47) | CA12CA1CA9LEF1 | |
| SCHEMBL28701306 | 0.77 | HTR2C (0.50) | CA12CA1CA9PSMB8LEF1 | |
| SCHEMBL2055341 | 0.77 | CA1 (0.45) | CA12CA1CA9PSMB8LEF1 | |
| SCHEMBL14554346 | 0.76 | TRPV1 (0.62) | — | |
| SCHEMBL4314672 | 0.76 | CA12 (0.49) | CA12CA1CA9PSMB8MAP4K4 | |
| SCHEMBL17668202 | 0.75 | CA12 (0.42) | CA12CA1CA9PSMB8LEF1 | |
| SCHEMBL14079744 | 0.74 | LDHA (0.67) | — | |
| SCHEMBL31736749 | 0.73 | CA12 (0.53) | CA12CA1CA9PSMB8MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114075189-A | Five-membered heterocyclic acene ring compound and preparation method and medical application thereof | 南京柯菲平盛辉制药有限公司 | 2022-02-22 | — | — | CN | disclosed |
| US-20210115029-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2021-04-22 | — | — | US | disclosed |
| US-20210115029-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2021-04-22 | — | — | US | disclosed |
| US-10669265-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2020-06-02 | — | — | US | disclosed |
| US-10669265-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2020-06-02 | — | — | US | disclosed |
| US-10633373-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2020-04-28 | — | — | US | disclosed |
| US-10633373-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2020-04-28 | — | — | US | disclosed |
| US-20180111921-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2018-04-26 | — | — | US | disclosed |
| US-20180111921-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2018-04-26 | — | — | US | disclosed |
| US-20180111921-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2018-04-26 | — | — | US | disclosed |
| US-9868726-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2018-01-16 | — | — | US | disclosed |
| US-20170107210-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2017-04-20 | — | — | US | disclosed |
| US-20170107210-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2017-04-20 | — | — | US | disclosed |
| US-20170107210-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2017-04-20 | — | — | US | disclosed |
| US-9371314-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2016-06-21 | — | — | US | disclosed |
| US-9371314-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2016-06-21 | — | — | US | disclosed |
| US-9371314-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2016-06-21 | — | — | US | disclosed |
| US-20160102080-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN, INC. | 2016-04-14 | — | — | US | disclosed |
| US-20160102080-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN, INC. | 2016-04-14 | — | — | US | disclosed |
| US-20160102080-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN, INC. | 2016-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102080-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | CA12 4882/4885CA1 4884/4885CA9 4665/4885 |
| US-10633373-B2 | Pyridyl benzothiophenes as kinase inhibitors | PDXK, MAP4K5, MAP4K2 | CA12 4882/4885CA1 4884/4885CA9 4665/4885 |
| US-20180111921-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | CA12 4882/4885CA1 4884/4885CA9 4665/4885 |
| US-20170107210-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | CA12 4882/4885CA1 4884/4885CA9 4665/4885 |
| US-20210115029-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | CA12 4882/4885CA1 4884/4885CA9 4665/4885 |
| US-10669265-B2 | Pyridyl benzothiophenes as kinase inhibitors | PDXK, MAP4K5, MAP4K2 | CA12 4882/4885CA1 4884/4885CA9 4665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.