Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.63 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.63 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.63 |
| ▸ | DRD1 | P21728 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LIPE | Q05469 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17674644 | 0.83 | DRD1 (0.61) | TAS1R3TAS1R1TAS1R2DRD1GAA | |
| SCHEMBL17674643 | 0.82 | DRD1 (0.52) | TAS1R3TAS1R1TAS1R2DRD1GAA | |
| SCHEMBL17674616 | 0.81 | DRD1 (0.67) | TAS1R3TAS1R1TAS1R2DRD1GAA | |
| SCHEMBL17674575 | 0.81 | DRD1 (0.67) | TAS1R3TAS1R1TAS1R2DRD1GAA | |
| SCHEMBL17674681 | 0.81 | DRD1 (0.67) | TAS1R3TAS1R1TAS1R2DRD1GAA | |
| SCHEMBL25206140 | 0.81 | DRD1 (0.55) | DRD1GAAMAPTMEN1KMT2A | |
| SCHEMBL30446366 | 0.81 | DRD1 (0.55) | DRD1GAAMAPTMEN1KMT2A | |
| SCHEMBL17674734 | 0.80 | SMN1; SMN2 (0.61) | DRD1MEN1KMT2APOLBNPC1 | |
| SCHEMBL17674641 | 0.79 | DRD1 (0.49) | TAS1R3TAS1R1TAS1R2DRD1MAPT | |
| SCHEMBL17674635 | 0.79 | TRPM8 (0.63) | TAS1R3TAS1R1DRD1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204359-B1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB Biopharma SRL (BE) | 2020-07-01 | — | — | EP | disclosed |
| US-10105359-B2 | Tetrahydroisoquinoline derivatives | UCB BIOPHARMA SPRL (BE) | 2018-10-23 | — | — | US | disclosed |
| US-20170304292-A1 | Tetrahydroisoquinoline Derivatives | UCB BIOPHARMA SPRL (BE) | 2017-10-26 | — | — | US | disclosed |
| EP-3204359-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB Biopharma SPRL (BE) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016055479-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2016-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170304292-A1 | Tetrahydroisoquinoline Derivatives | OPRD1, ADRA1D, GPR52 | TAS1R3 1277/4885TAS1R1 750/4885TAS1R2 941/4885 |
| US-10105359-B2 | Tetrahydroisoquinoline derivatives | OPRD1, ADRA1D, GPR52 | TAS1R3 1277/4885TAS1R1 750/4885TAS1R2 941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.