Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25206140 | 1.00 | DRD1 (0.55) | DRD1NPC1POLBKMT2AALDH1A1 | |
| SCHEMBL25211419 | 0.85 | KMT2A (0.60) | DRD1NPC1POLBKMT2AALDH1A1 | |
| SCHEMBL23327029 | 0.84 | NPC1 (0.68) | DRD1NPC1POLBKMT2AMEN1 | |
| SCHEMBL17674616 | 0.82 | DRD1 (0.67) | DRD1NPC1POLBKMT2AALDH1A1 | |
| SCHEMBL17674575 | 0.82 | DRD1 (0.67) | DRD1NPC1POLBKMT2AALDH1A1 | |
| SCHEMBL17674681 | 0.82 | DRD1 (0.67) | DRD1NPC1POLBKMT2AALDH1A1 | |
| SCHEMBL17674643 | 0.81 | DRD1 (0.52) | DRD1NPC1POLBKMT2AMEN1 | |
| SCHEMBL17674604 | 0.81 | TAS1R3 (0.63) | DRD1NPC1POLBKMT2AMEN1 | |
| SCHEMBL17674644 | 0.79 | DRD1 (0.61) | DRD1NPC1POLBKMT2AMEN1 | |
| SCHEMBL17674718 | 0.78 | DRD1 (0.60) | DRD1NPC1POLBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174530-A1 | N-(PHENYLAMINOCARBONYL) TETRAHYDRO-ISOQUINOLINES AND RELATED COMPOUNDS AS MODULATORS OF GPR65 | Pathios Therapeutics Limited (GB) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174530-A1 | N-(PHENYLAMINOCARBONYL) TETRAHYDRO-ISOQUINOLINES AND RELATED COMPOUNDS AS MODULATORS OF GPR65 | GPR3, GPR65, GPR52 | DRD1 868/4885NPC1 579/4885POLB 3912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.