SCHEMBL17680368

SCHEMBL17680368

Cc1cc(C)cc(-c2ccc3c(CCC(C)C(F)(F)F)cccc3n2)c1

nearest known ligand 0.32

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
AR P10275 2/20 0.32
LMNA P02545 1/20 0.32
DHODH Q02127 1/20 0.31
ACP1 P24666 1/20 0.30
SYK P43405 1/20 0.30
TLR7 Q9NYK1 1/20 0.30
ABCB1 P08183 1/20 0.30
MAPT P10636 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
ABCG2 Q9UNQ0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17666817 0.89 AR (0.33) ARLMNADHODHACP1SYK
SCHEMBL13732292 0.86 NOS3 (0.39) DHODHSYKABCB1MAPTSMN1; SMN2
SCHEMBL17666818 0.83 CDK9 (0.35) ARLMNADHODHACP1TLR7
SCHEMBL17680359 0.79 TLR8 (0.39) LMNADHODHMAPTSMN1; SMN2
SCHEMBL10319231 0.78 DHODH (0.40) LMNADHODHMAPTSMN1; SMN2
SCHEMBL20809038 0.78 LMNA (0.37) ARLMNADHODHACP1
SCHEMBL28865796 0.77 AR (0.31) ARLMNA
SCHEMBL13731884 0.77 GRM2 (0.35) ARLMNAABCB1MAPTSMN1; SMN2
SCHEMBL28865795 0.75 KMT2A (0.34) LMNADHODHMAPTSMN1; SMN2
SCHEMBL24513499 0.75 TACR3 (0.36) LMNADHODHMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180190914-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2018-07-05 US disclosed
US-20170352821-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2017-12-07 US disclosed
US-9799838-B2 Fluorinated organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2017-10-24 US disclosed
US-20160285013-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2016-09-29 US disclosed
US-9397302-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2016-07-19 US disclosed
US-20160104848-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2016-04-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170352821-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES ORC3, OCIAD1, ICOSLG AR 2637/4885LMNA 1339/4885DHODH 1456/4885
US-20180190914-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES ORC3, OCIAD1, ICOSLG AR 2637/4885LMNA 1339/4885DHODH 1456/4885
US-20160104848-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES ORC3, FARS2, FARSA AR 3476/4885LMNA 1931/4885DHODH 1526/4885
US-20160285013-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES ORC3, FARS2, FARSA AR 3476/4885LMNA 1931/4885DHODH 1526/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.