SCHEMBL176841

SCHEMBL176841

COC(=O)c1cc(Cl)cc(N)c1Cl

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.64
CYP3A4 P08684 1/20 0.61
GAA P10253 5/20 0.51
NQO2 P16083 3/20 0.49
KDM4E B2RXH2 6/20 0.49
ALDH1A1 P00352 5/20 0.47
HSD17B10 Q99714 3/20 0.47
MAPT P10636 3/20 0.47
HPGD P15428 2/20 0.47
GLA P06280 2/20 0.47
CASP1 P29466 1/20 0.47
CASP7 P55210 1/20 0.47
ATM Q13315 1/20 0.47
CFTR P13569 2/20 0.47
SERPINH1 P50454 1/20 0.45
ALOX15 P16050 1/20 0.45
TSHR P16473 1/20 0.45
SLC6A4 P31645 1/20 0.44
SLC6A3 Q01959 1/20 0.44
PDK2 Q15119 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL36846569 1.00 ABL1 (0.64) ABL1CYP3A4GAANQO2KDM4E
SCHEMBL505256 0.85 ABL1 (0.64) ABL1CYP3A4GAANQO2KDM4E
SCHEMBL31636576 0.84 ABL1 (0.62) ABL1CYP3A4GAANQO2KDM4E
SCHEMBL1549467 0.84 ABL1 (0.62) ABL1CYP3A4GAANQO2KDM4E
SCHEMBL28665944 0.84 KDM4E (0.59) ABL1CYP3A4GAANQO2KDM4E
SCHEMBL25612414 0.84 ABL1 (0.53) ABL1CYP3A4GAANQO2KDM4E
SCHEMBL12499408 0.84 ABL1 (0.62) ABL1CYP3A4GAANQO2KDM4E
SCHEMBL1461725 0.82 ABL1 (0.60) ABL1CYP3A4GAANQO2KDM4E
SCHEMBL13280615 0.82 ABL1 (0.60) ABL1CYP3A4GAANQO2KDM4E
SCHEMBL13280732 0.82 ABL1 (0.60) ABL1CYP3A4GAAKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4337017-A1 HERBICIDE/SAFENER COMBINATION BASED ON SAFENERS FROM THE CLASS OF SUBSTITUTED [(1,5-DIPHENYL-1H-1,2,4-TRIAZOL-3-YL)OXY]ACETIC ACIDS AND THEIR SALTS Bayer Aktiengesellschaft (DE) 2024-03-20 EP claimed
WO-2022152728-A1 HERBICIDAL COMPOSITIONS BAYER AKTIENGESELLSCHAFT (DE) 2022-07-21 WO claimed
EP-4719606-A2 GCN2 AND PERK KINASE MODULATORS AND METHODS OF USE THEREOF Deciphera Pharmaceuticals, LLC (US) 2026-04-08 EP disclosed
US-20260049039-A1 MICROFIBRILLATED CELLULOSE AS RHEOLOGY MODIFIER IN HIGH IONIC STRENGTH AGRICULTURAL FORMULATIONS AMVAC CHEMICAL CORP (US) 2026-02-19 US disclosed
US-20250281926-A1 SAMPLE MANIPULATION AND ASSAY WITH RAPID TEMPERATURE CHANGE ESSENLIX CORPORATION (US) 2025-09-11 US disclosed
EP-4605378-A2 BROMINE- OR IODINE-PARA-SUBSTITUTED [(1,5-DIPHENYL-1H-1,2,4-TRIAZOL-3-YL)OXY]ACETIC ACID DERIVATIVES AND THEIR SALTS, AGENTS FOR PROTECTING USEFUL PLANTS OR CROP PLANTS COMPRISING THEM, METHODS FOR PRODUCING THEM AND THEIR USE AS SAFENERS Bayer Aktiengesellschaft (DE) 2025-08-27 EP disclosed
US-12378165-B2 Pesticide formulation comprising MFC as rheology modifier AMVAC CHEMICAL CORPORATION (US) 2025-08-05 US disclosed
US-20250128993-A1 AGRICULTURAL ADJUVANT COMPRISING MICROFIBRILLATED CELLULOSE AMVAC CHEMICAL CORPORATION 2025-04-24 US disclosed
US-20250099965-A1 RAPID SAMPLE TEMPERATURE CHANGING FOR ASSAYING ESSENLIX CORPORATION (US) 2025-03-27 US disclosed
US-12226769-B2 Sample manipulation and assay with rapid temperature change ESSENLIX CORPORATION (US) 2025-02-18 US disclosed
WO-2024249493-A2 GCN2 AND PERK KINASE MODULATORS AND METHODS OF USE THEREOF DECIPHERA PHARMACEUTICALS, LLC (US) 2024-12-05 WO disclosed
US-20060276339-A1 Methods and compositions for increasing the efficacy of biologically-active ingredients BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2006-12-07 US disclosed
EP-1724268-A1 COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-11-22 EP disclosed
US-20060229336-A1 Ccr5 antagonists as therapeutic agents SMITHKLINE BEECHAM CORPORATION 2006-10-12 US disclosed
EP-1569646-A2 PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2005-09-07 EP disclosed
EP-1041980-B1 ACYL GUANIDINE SODIUM/PROTON EXCHANGE INHIBITORS AND METHOD BRISTOL MYERS SQUIBB CO (US) 2005-02-23 EP disclosed
WO-2004054974-A2 PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2004-07-01 WO disclosed
US-6011059-A PREVENTING OR TREATING ANGINA PECTORIS, CARDIAC DYSFUNCTION, MYOCARDIAL NECROSIS, AND ARRHYTHMIA EMPLOYING THE ABOVE ACYL GUANIDINES. BRISTOL-MYERS SQUIBB COMPANY (US) 2000-01-04 US disclosed
US-4344857-A Encapsulation by entrapment THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1982-08-17 US disclosed
US-4104049-A Chlorine-substituted vinylaminobenzoic acid compounds and plant growth regulant compositions BAYER AKTIENGESELLSCHAFT (DE) 1978-08-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260049039-A1 MICROFIBRILLATED CELLULOSE AS RHEOLOGY MODIFIER IN HIGH IONIC STRENGTH AGRICULTURAL FORMULATIONS FIBP, GHDC, MASTL ABL1 2629/4885CYP3A4 4392/4885GAA 2440/4885
US-20060276339-A1 Methods and compositions for increasing the efficacy of biologically-active ingredients ENPP1, ENPP3, SMPD1 ABL1 555/4885CYP3A4 2428/4885GAA 111/4885
US-12378165-B2 Pesticide formulation comprising MFC as rheology modifier MFAP1, PFAS, DDT ABL1 4877/4885CYP3A4 774/4885GAA 3472/4885
US-20060229336-A1 Ccr5 antagonists as therapeutic agents CCR5, CCR1, CXCR3 ABL1 2333/4885CYP3A4 1724/4885GAA 2640/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.