Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11805 | 1.00 | PIK3CD (0.33) | PIK3CDNR1H4HSD17B10KDM4EALDH1A1 | |
| SCHEMBL16665403 | 0.93 | ALDH1A1 (0.32) | NR1H4KDM4EALDH1A1SLC6A9 | |
| SCHEMBL27149664 | 0.89 | HSD17B10 (0.40) | HSD17B10KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1515804 | 0.89 | HSD17B10 (0.40) | HSD17B10KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL31696657 | 0.89 | HSD17B10 (0.40) | HSD17B10KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL31623264 | 0.85 | HSD11B1 (0.33) | — | |
| SCHEMBL428708 | 0.85 | — | — | |
| SCHEMBL1341780 | 0.81 | CES2 (0.39) | HSD17B10KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1340689 | 0.81 | RIPK1 (0.35) | HSD17B10KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL18358256 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | disclosed |