SCHEMBL17685358

SCHEMBL17685358

CC(C)[C@H](N)[C@H](O)C(=O)N[C@H]1CCCCNC1=O

nearest known ligand 0.58

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 6/20 0.58
MMP3 P08254 2/20 0.58
MMP2 P08253 1/20 0.58
MMP7 P09237 1/20 0.58
MMP8 P22894 1/20 0.58
CCR2 P41597 12/20 0.55
RAB9A P51151 1/20 0.48
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20211170 1.00 MMP1 (0.58) MMP1MMP3MMP2MMP7MMP8
SCHEMBL18467797 1.00 MMP1 (0.58) MMP1MMP3MMP2MMP7MMP8
SCHEMBL17683900 1.00 MMP1 (0.58) MMP1MMP3MMP2MMP7MMP8
Hydrochloric Acid SCHEMBL17685539 0.99 MMP1 (0.57) MMP1MMP3MMP2MMP7MMP8
Hydrochloric Acid SCHEMBL25344436 0.83 CCR2 (0.60) MMP1MMP3MMP2MMP7MMP8
Hydrochloric Acid SCHEMBL25344446 0.83 CCR2 (0.60) MMP1MMP3MMP2MMP7MMP8
Hydrochloric Acid SCHEMBL25344442 0.83 CCR2 (0.60) MMP1MMP3MMP2MMP7MMP8
SCHEMBL12875983 0.82 CCR2 (0.64) MMP1MMP3MMP2MMP7MMP8
SCHEMBL12155589 0.82 CCR2 (0.64) MMP1MMP3MMP2MMP7MMP8
SCHEMBL7372465 0.78 MMP1 (0.66) MMP1MMP3MMP2MMP7MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3009425-B1 ALPHA-OXOACYLAMINOCAPROLACTAM SEIKAGAKU KOGYO CO LTD (JP) 2018-06-06 EP disclosed
EP-3009425-B1 ALPHA-OXOACYLAMINOCAPROLACTAM SEIKAGAKU KOGYO CO LTD (JP) 2018-06-06 EP disclosed
EP-3009444-B1 ALPHA-OXOACYL AMINO-CAPROLACTAM DERIVATIVE SEIKAGAKU KOGYO CO LTD (JP) 2017-12-20 EP disclosed
EP-3009444-B1 ALPHA-OXOACYL AMINO-CAPROLACTAM DERIVATIVE SEIKAGAKU KOGYO CO LTD (JP) 2017-12-20 EP disclosed
US-9636346-B2 Alpha-oxoacyl amino-caprolactam derivative SEIKAGAKU CORPORATION (JP) 2017-05-02 US disclosed
US-9636346-B2 Alpha-oxoacyl amino-caprolactam derivative SEIKAGAKU CORPORATION (JP) 2017-05-02 US disclosed
US-9562042-B2 α-oxoacyl amino-caprolactam SEIKAGAKU CORPORATION (JP) 2017-02-07 US disclosed
US-9562042-B2 α-oxoacyl amino-caprolactam SEIKAGAKU CORPORATION (JP) 2017-02-07 US disclosed
US-20160375031-A1 ALPHA-OXOACYL AMINO-CAPROLACTAM DERIVATIVE SEIKAGAKU KOGYO CO LTD (JP) 2016-12-29 US disclosed
US-9481707-B2 α-oxoacyl amino-caprolactam derivative SEIKAGAKU CORPORATION (JP) 2016-11-01 US disclosed
US-9481707-B2 α-oxoacyl amino-caprolactam derivative SEIKAGAKU CORPORATION (JP) 2016-11-01 US disclosed
US-20160137691-A1 ALPHA-OXOACYL AMINO-CAPROLACTAM DERIVATIVE SEIKAGAKU CORPORATION (JP) 2016-05-19 US disclosed
US-20160137691-A1 ALPHA-OXOACYL AMINO-CAPROLACTAM DERIVATIVE SEIKAGAKU CORPORATION (JP) 2016-05-19 US disclosed
US-20160130266-A1 ALPHA-OXOACYL AMINO-CAPROLACTAM BODY SEIKAGAKU CORPORATION (JP) 2016-05-12 US disclosed
US-20160130266-A1 ALPHA-OXOACYL AMINO-CAPROLACTAM BODY SEIKAGAKU CORPORATION (JP) 2016-05-12 US disclosed
EP-3009425-A1 ALPHA-OXOACYL AMINO-CAPROLACTAM BODY Seikagaku Corporation (JP) 2016-04-20 EP disclosed
EP-3009444-A1 ALPHA-OXOACYL AMINO-CAPROLACTAM DERIVATIVE Seikagaku Corporation (JP) 2016-04-20 EP disclosed
EP-3009444-A1 ALPHA-OXOACYL AMINO-CAPROLACTAM DERIVATIVE Seikagaku Corporation (JP) 2016-04-20 EP disclosed
EP-3009425-A1 ALPHA-OXOACYL AMINO-CAPROLACTAM BODY Seikagaku Corporation (JP) 2016-04-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160375031-A1 ALPHA-OXOACYL AMINO-CAPROLACTAM DERIVATIVE OGFRL1, ARGLU1, COL1A1 MMP1 605/4885MMP3 1193/4885MMP2 929/4885
US-20160137691-A1 ALPHA-OXOACYL AMINO-CAPROLACTAM DERIVATIVE COL2A1, ARGLU1, COL1A1 MMP1 798/4885MMP3 1587/4885MMP2 1137/4885
US-20160130266-A1 ALPHA-OXOACYL AMINO-CAPROLACTAM BODY ANPEP, COL2A1, PTMS MMP1 838/4885MMP3 1149/4885MMP2 483/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.