Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 3/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000654 | 1.00 | PRCP (0.49) | PRCPDPP4GRM8GRM4ROCK2 | |
| SCHEMBL31000717 | 1.00 | PRCP (0.49) | PRCPDPP4GRM8GRM4ROCK2 | |
| SCHEMBL1768751 | 1.00 | PRCP (0.49) | PRCPDPP4GRM8GRM4ROCK2 | |
| SCHEMBL4128071 | 0.86 | PRCP (0.42) | PRCPDPP4GRM8GRM4ROCK2 | |
| SCHEMBL24156377 | 0.82 | DPP4 (0.51) | DPP4SLC7A5ALDH1A1 | |
| SCHEMBL383451 | 0.82 | DPP4 (0.51) | DPP4SLC7A5ALDH1A1 | |
| SCHEMBL30360242 | 0.82 | DPP4 (0.51) | DPP4SLC7A5ALDH1A1 | |
| SCHEMBL8882516 | 0.82 | DPP4 (0.51) | DPP4SLC7A5ALDH1A1 | |
| SCHEMBL180086 | 0.82 | DPP4 (0.51) | DPP4SLC7A5ALDH1A1 | |
| SCHEMBL383452 | 0.82 | DPP4 (0.51) | DPP4SLC7A5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240287138-A1 | CYCLIC PEPTIDES FOR INHIBITING TNF RECEPTOR 1 ACTIVITY | MERCK SHARP & DOHME LLC | 2024-08-29 | — | — | US | disclosed |
| EP-3280723-B1 | BACKBONE-CYCLIZED PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2021-01-06 | — | — | EP | disclosed |
| US-10730911-B2 | Backbone-cyclized peptidomimetics with GLP-1R modulating activity | UNIVERSITAT ZURICH (CH) | 2020-08-04 | — | — | US | disclosed |
| US-9957297-B2 | Template-fixed peptidomimetics as inhibitors of FPR1 | POLYPHOR AG (CH) | 2018-05-01 | — | — | US | disclosed |
| US-20180072774-A1 | BACKBONE-CYCLIZED PEPTIDOMIMETICS WITH GLP-1R MODULATING ACTIVITY | POLYPHOR AG (CH) | 2018-03-15 | — | — | US | disclosed |
| EP-3280723-A1 | BACKBONE-CYCLIZED PEPTIDOMIMETICS | Polyphor AG (CH) | 2018-02-14 | — | — | EP | disclosed |
| EP-2764010-B9 | TEMPLATE-FIXED PEPTIDOMIMETICS AS INHIBITORS OF FPR1 | POLYPHOR AG (CH) | 2017-01-18 | — | — | EP | disclosed |
| WO-2016162127-A1 | BACKBONE-CYCLIZED PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2016-10-13 | — | — | WO | disclosed |
| EP-2764010-B1 | TEMPLATE-FIXED PEPTIDOMIMETICS AS INHIBITORS OF FPR1 | POLYPHOR AG (CH) | 2016-03-16 | — | — | EP | disclosed |
| US-20140287986-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS AS INHIBITORS OF FPR1 | POLYPHOR AG (CH) | 2014-09-25 | — | — | US | disclosed |
| US-8754038-B2 | Template-fixed peptidomimetics with CCR10 antagonistic activity | POLYPHOR AG (CH) | 2014-06-17 | — | — | US | disclosed |
| US-20120283168-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVITY | POLYPHOR AG (CH) | 2012-11-08 | — | — | US | disclosed |
| EP-2501715-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVTY | Polyphor Ag (CH) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060937-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVTY | POLYPHOR AG (CH) | 2011-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140287986-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS AS INHIBITORS OF FPR1 | FPR1, FPR3, FPR2 | PRCP 1978/4885DPP4 3508/4885GRM8 1063/4885 |
| US-20180072774-A1 | BACKBONE-CYCLIZED PEPTIDOMIMETICS WITH GLP-1R MODULATING ACTIVITY | GLP1R, GIPR, SSTR1 | PRCP 1029/4885DPP4 65/4885GRM8 1338/4885 |
| US-10730911-B2 | Backbone-cyclized peptidomimetics with GLP-1R modulating activity | GLP1R, GIPR, SSTR1 | PRCP 1029/4885DPP4 65/4885GRM8 1338/4885 |
| US-20120283168-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVITY | CCR10, CCR1, CCRL2 | PRCP 1285/4885DPP4 2377/4885GRM8 1650/4885 |
| US-20240287138-A1 | CYCLIC PEPTIDES FOR INHIBITING TNF RECEPTOR 1 ACTIVITY | TNF, TNFRSF1A, CD40 | PRCP 902/4885DPP4 1135/4885GRM8 3419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.