Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 3/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CCL2 | P13500 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17688567 | 1.00 | PSIP1 (0.52) | PSIP1GAARORCFTOCHRM2 | |
| SCHEMBL17688628 | 1.00 | PSIP1 (0.52) | PSIP1GAARORCFTOCHRM2 | |
| SCHEMBL27795 | 0.77 | HTR6 (0.54) | GAACHRM2CHRM5CHRM1CHRM4 | |
| SCHEMBL10455034 | 0.76 | PSIP1 (0.74) | PSIP1GAAALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL4158886 | 0.76 | PTAFR (0.37) | — | |
| SCHEMBL17688574 | 0.73 | CHRM2 (0.48) | PSIP1GAARORCCHRM2CHRM5 | |
| SCHEMBL24793061 | 0.70 | LMNA (0.50) | GAACHRM2CHRM5CHRM1CHRM4 | |
| SCHEMBL180713 | 0.69 | PSIP1 (1.00) | PSIP1GAAALDH1A1HSD11B1 | |
| SCHEMBL10181940 | 0.69 | RORC (0.62) | PSIP1GAARORCALDH1A1KMT2A | |
| SCHEMBL5052716 | 0.68 | RORC (0.64) | PSIP1GAARORCALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3207043-A1 | DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA | Vitae Pharmaceuticals, Inc. (US) | 2017-08-23 | — | — | EP | disclosed |
| WO-2016061160-A1 | DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA | VITAE PHARMACEUTICALS, INC. (US) | 2016-04-21 | — | — | WO | disclosed |