Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | BCL2 | P10415 | 3/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | APAF1 | O14727 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CDC25B | P30305 | 1/20 | 0.33 |
| ▸ | USP1 | O94782 | 1/20 | 0.33 |
| ▸ | USP19 | O94966 | 1/20 | 0.33 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12960697 | 0.78 | STAT3 (0.56) | STAT3ALDH1A1BCL2MCL1MAPT | |
| SCHEMBL16917433 | 0.76 | STAT3 (0.76) | STAT3ALDH1A1BCL2MCL1MAPT | |
| SCHEMBL19820871 | 0.76 | STAT3 (0.57) | STAT3ALDH1A1BCL2MCL1MAPT | |
| SCHEMBL12960696 | 0.75 | ALDH1A1 (0.56) | STAT3ALDH1A1MAPTKMT2AHTT | |
| Napabucasin SCHEMBL29349770 | 0.72 | STAT3 (1.00) | STAT3ALDH1A1BCL2MCL1MAPT | |
| SCHEMBL12640087 | 0.72 | STAT3 (0.75) | STAT3ALDH1A1BCL2MCL1MAPT | |
| Napabucasin SCHEMBL1883845 | 0.72 | STAT3 (1.00) | STAT3ALDH1A1BCL2MCL1MAPT | |
| SCHEMBL18691843 | 0.71 | STAT3 (0.73) | STAT3ALDH1A1BCL2MCL1MAPT | |
| SCHEMBL12640086 | 0.71 | STAT3 (0.73) | STAT3ALDH1A1BCL2MCL1MAPT | |
| SCHEMBL19824423 | 0.70 | STAT3 (0.49) | STAT3ALDH1A1MAPTKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3050566-A2 | A NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS | Boston Biomedical, Inc. (US) | 2016-08-03 | — | — | EP | disclosed |
| EP-2190429-B1 | A NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS | BOSTON BIOMEDICAL INC (US) | 2016-04-20 | — | — | EP | disclosed |