Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 6/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | USP1 | O94782 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Napabucasin SCHEMBL1883845 | 0.86 | STAT3 (1.00) | STAT3ALDH1A1MAPTHTTLMNA | |
| Napabucasin SCHEMBL29349770 | 0.86 | STAT3 (1.00) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL19597404 | 0.80 | STAT3 (0.79) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL12640087 | 0.79 | STAT3 (0.75) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL18730820 | 0.79 | STAT3 (0.69) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL12494612 | 0.79 | STAT3 (0.73) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL12640086 | 0.78 | STAT3 (0.73) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL18691843 | 0.78 | STAT3 (0.73) | STAT3ALDH1A1MAPTHTTLMNA | |
| SCHEMBL19820871 | 0.77 | STAT3 (0.57) | STAT3ALDH1A1MAPTHTTLMNA | |
| Napabucasin SCHEMBL3654300 | 0.76 | STAT3 (0.78) | STAT3ALDH1A1MAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133695-A1 | METHODS AND COMPOSITIONS FOR REJUVENATING CNS GLIAL POPULATIONS BY SUPPRESION OF TRANSCRIPTION FACTORS | UNIVERSITY OF ROCHESTER | 2023-05-04 | — | — | US | disclosed |
| EP-3108750-B1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS | 1GLOBE BIOMEDICAL CO LTD (CN) | 2018-07-04 | — | — | EP | disclosed |
| US-20180140572-A1 | COMPOSITIONS COMPRISING A CANCER STEMNESS INHIBITOR AND AN IMMUNOTHERAPEUTIC AGENT FOR USE IN TREATING CANCER | BOSTON BIOMEDICAL, INC. | 2018-05-24 | — | — | US | disclosed |
| US-20180098959-A1 | METHODS FOR TREATING CANCER | BOSTON BIOMEDICAL, INC. (US) | 2018-04-12 | — | — | US | disclosed |
| US-20180085341-A1 | METHODS FOR TREATING CANCER | BOSTON BIOMEDICAL, INC. (US) | 2018-03-29 | — | — | US | disclosed |
| US-9381184-B2 | Compounds and compositions for targeting cancer stem cells | BOSTON BIOMEDICAL, INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-20160030384-A1 | 2-ACETYLNAPHTHO[2,3-B]FURAN -4,9-DIONE FOR USE ON TREATING CANCER | BOSTON BIOMEDICAL, INC. (US) | 2016-02-04 | — | — | US | disclosed |
| US-9084766-B2 | Compounds and compositions for targeting cancer stem cells | BOSTON BIOMEDICAL, INC. (US) | 2015-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133695-A1 | METHODS AND COMPOSITIONS FOR REJUVENATING CNS GLIAL POPULATIONS BY SUPPRESION OF TRANSCRIPTION FACTORS | IKZF3, IKZF1, CXXC4 | STAT3 8/4885ALDH1A1 3617/4885MAPT 3029/4885 |
| US-20160030384-A1 | 2-ACETYLNAPHTHO[2,3-B]FURAN -4,9-DIONE FOR USE ON TREATING CANCER | B3GNT2, NAT1, NQO1 | STAT3 4742/4885ALDH1A1 65/4885MAPT 2559/4885 |
| US-20180098959-A1 | METHODS FOR TREATING CANCER | FOLR2, TP53, EGFR | STAT3 934/4885ALDH1A1 1188/4885MAPT 2995/4885 |
| US-20180140572-A1 | COMPOSITIONS COMPRISING A CANCER STEMNESS INHIBITOR AND AN IMMUNOTHERAPEUTIC AGENT FOR USE IN TREATING CANCER | CD44, CD47, BMI1 | STAT3 4/4885ALDH1A1 58/4885MAPT 4375/4885 |
| US-20180085341-A1 | METHODS FOR TREATING CANCER | TP53, TUBB1, TUBB3 | STAT3 1235/4885ALDH1A1 742/4885MAPT 1502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.