Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | APAF1 | O14727 | 3/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12960696 | 0.91 | ALDH1A1 (0.56) | STAT3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL19820871 | 0.80 | STAT3 (0.57) | STAT3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL12960697 | 0.80 | STAT3 (0.56) | STAT3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL16917433 | 0.71 | STAT3 (0.76) | STAT3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL12640088 | 0.71 | ALDH1A1 (0.66) | STAT3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL12494612 | 0.70 | STAT3 (0.73) | STAT3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL17690053 | 0.70 | STAT3 (0.56) | STAT3ALDH1A1MAPTLMNASMN1; SMN2 | |
| Napabucasin SCHEMBL29349770 | 0.68 | STAT3 (1.00) | STAT3ALDH1A1MAPTLMNASMN1; SMN2 | |
| Napabucasin SCHEMBL1883845 | 0.68 | STAT3 (1.00) | STAT3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL17345477 | 0.67 | STAT3 (0.64) | STAT3ALDH1A1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200039948-A1 | NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS | BOSTON BIOMEDICAL, INC. | 2020-02-06 | — | — | US | disclosed |
| US-20180030022-A1 | NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS | BOSTON BIOMEDICAL, INC. (US) | 2018-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180030022-A1 | NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS | STAT3, JAK2, STAT5B | STAT3 1/4885ALDH1A1 765/4885MAPT 4567/4885 |
| US-20200039948-A1 | NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS | STAT3, JAK2, STAT5B | STAT3 1/4885ALDH1A1 765/4885MAPT 4567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.