Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 5/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 4/20 | 0.41 |
| ▸ | DRD1 | P21728 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770307 | 0.90 | MTNR1A (0.47) | MTNR1AMTNR1BCYP3A4CYP19A1CYP11B1 | |
| SCHEMBL1770654 | 0.83 | MTNR1A (0.46) | MTNR1AMTNR1BDRD4HTR2A | |
| SCHEMBL1770605 | 0.76 | MTNR1A (0.55) | MTNR1AMTNR1B | |
| SCHEMBL6287541 | 0.72 | PDE4A (0.40) | DRD3DRD2DRD4 | |
| SCHEMBL12598196 | 0.72 | MTNR1A (0.53) | MTNR1AMTNR1BCYP3A4DRD3DRD2 | |
| SCHEMBL1770499 | 0.71 | MTNR1A (0.50) | MTNR1AMTNR1BCYP3A4REN | |
| SCHEMBL1771027 | 0.70 | MTNR1B (0.52) | MTNR1AMTNR1BCYP3A4REN | |
| SCHEMBL12598202 | 0.70 | MTNR1A (0.48) | MTNR1AMTNR1BCYP3A4HTR2AREN | |
| SCHEMBL8302626 | 0.70 | HDAC1 (0.54) | MTNR1AMTNR1BCYP3A4REN | |
| SCHEMBL1770990 | 0.69 | MTNR1A (0.53) | MTNR1AMTNR1BCYP3A4REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112148-A1 | INDOLINE COMPOUNDS | FERRER INTERNACIONAL S.A. | 2011-05-12 | — | — | US | claimed |
| EP-2203423-A1 | INDOLINE COMPOUNDS | Ferrer Internacional, S.A. (ES) | 2010-07-07 | — | — | EP | claimed |
| WO-2009053440-A1 | INDOLINE COMPOUNDS | FERRER INTERNACIONAL S.A. (ES) | 2009-04-30 | — | — | WO | claimed |
| US-20110112148-A1 | INDOLINE COMPOUNDS | FERRER INTERNACIONAL S.A. | 2011-05-12 | — | — | US | disclosed |
| EP-2203423-A1 | INDOLINE COMPOUNDS | Ferrer Internacional, S.A. (ES) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009053440-A1 | INDOLINE COMPOUNDS | FERRER INTERNACIONAL S.A. (ES) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112148-A1 | INDOLINE COMPOUNDS | MTNR1A, MTNR1B, TPH2 | MTNR1A 1/4885PDCD1 3297/4885CD274 4398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.