Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17709777 | 1.00 | MEN1 (0.36) | MEN1ALDH1A1KMT2A | |
| SCHEMBL17709823 | 0.85 | MEN1 (0.35) | MEN1ALDH1A1KMT2A | |
| SCHEMBL17760480 | 0.81 | RAB9A (0.32) | MEN1ALDH1A1KMT2A | |
| SCHEMBL17709883 | 0.80 | ALDH1A1 (0.32) | MEN1ALDH1A1KMT2A | |
| SCHEMBL28494937 | 0.78 | NPC1 (0.35) | MEN1ALDH1A1KMT2A | |
| SCHEMBL17760523 | 0.78 | — | — | |
| SCHEMBL17709730 | 0.77 | NPC1 (0.34) | MEN1ALDH1A1KMT2A | |
| SCHEMBL17709731 | 0.77 | NPC1 (0.34) | MEN1ALDH1A1KMT2A | |
| SCHEMBL17709749 | 0.77 | ALDH1A1 (0.38) | MEN1ALDH1A1KMT2A | |
| SCHEMBL17712120 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108064224-B | Amide-substituted thiazoles as modulators of Ror gamma t | 詹森药业有限公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-107108598-B | Thiazoles as Ror gamma t modulators | 詹森药业有限公司 | 2020-11-17 | — | — | CN | disclosed |
| EP-3212642-B1 | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORGAMMAT | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-30 | — | — | EP | disclosed |
| EP-3212641-B1 | THIAZOLES AS MODULATORS OF RORYT | JANSSEN PHARMACEUTICA NV (BE) | 2018-12-05 | — | — | EP | disclosed |
| US-10080744-B2 | Thiazoles as modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2018-09-25 | — | — | US | disclosed |
| US-20180064690-A1 | THIAZOLES AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2018-03-08 | — | — | US | disclosed |
| US-9861618-B2 | Thiazoles as modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2018-01-09 | — | — | US | disclosed |
| US-9845319-B2 | Amide substituted thiazoles as modulators of RORyt | Janssen Pharmaceutiuca NV (BE) | 2017-12-19 | — | — | US | disclosed |
| EP-3212642-A1 | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORyT | Janssen Pharmaceutica NV (BE) | 2017-09-06 | — | — | EP | disclosed |
| WO-2016069978-A1 | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORγT | JANSSEN PHARMACEUTICA NV (BE) | 2016-05-06 | — | — | WO | disclosed |
| US-20160122335-A1 | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (US) | 2016-05-05 | — | — | US | disclosed |
| US-20160120850-A1 | THIAZOLES AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (US) | 2016-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160120850-A1 | THIAZOLES AS MODULATORS OF RORyt | RORC, RORB, RORA | MEN1 4081/4885ALDH1A1 529/4885KMT2A 2672/4885 |
| US-20160122335-A1 | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORyt | RORC, RORA, RORB | MEN1 4059/4885ALDH1A1 241/4885KMT2A 1610/4885 |
| US-10080744-B2 | Thiazoles as modulators of RORγt | RORB, RORA, RORC | MEN1 3635/4885ALDH1A1 466/4885KMT2A 2405/4885 |
| US-20180064690-A1 | THIAZOLES AS MODULATORS OF RORyt | RORC, RORB, RORA | MEN1 4093/4885ALDH1A1 716/4885KMT2A 2927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.