Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7237555 | 0.83 | MAPT (0.54) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL17737210 | 0.81 | NPC1 (0.50) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL1558275 | 0.81 | MAPT (0.58) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL17737250 | 0.81 | POLB (0.48) | MAPTNPC1RAB9APPARGKMT2A | |
| SCHEMBL5477871 | 0.79 | GAA (0.53) | MAPTKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL14865306 | 0.79 | PKM (0.54) | MAPTRAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL5713380 | 0.77 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5713303 | 0.76 | HTT (0.54) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL29606242 | 0.75 | MAPT (0.52) | MAPTNPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL6275597 | 0.74 | HTT (0.58) | MAPTNPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9638690-B2 | Compounds and compositions for use as alkylating agent sensors and methods of use thereof | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2017-05-02 | — | — | US | disclosed |
| US-20160131641-A1 | COMPOUNDS AND COMPOSITIONS FOR USE AS ALKYLATING AGENT SENSORS AND METHODS OF USE THEREOF | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2016-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160131641-A1 | COMPOUNDS AND COMPOSITIONS FOR USE AS ALKYLATING AGENT SENSORS AND METHODS OF USE THEREOF | MGMT, MCL1, OGG1 | MAPT 4487/4885NPC1 4446/4885RAB9A 3999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.