Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 2/20 | 0.56 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | SQSTM1 | Q13501 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17737455 | 0.91 | IDO1 (0.55) | ALOX12SLC40A1GLO1FFAR4RECQL | |
| SCHEMBL17737617 | 0.81 | RECQL (0.69) | ALOX12SLC40A1GLO1RECQLIDO1 | |
| SCHEMBL17737476 | 0.80 | ALOX12 (0.62) | ALOX12SLC40A1GLO1RECQLIDO1 | |
| SCHEMBL17737677 | 0.79 | RECQL (0.58) | ALOX12SLC40A1GLO1RECQLIDO1 | |
| SCHEMBL17737442 | 0.77 | GLO1 (0.62) | SLC40A1GLO1IDO1KMT2AMEN1 | |
| SCHEMBL22536978 | 0.77 | MAPT (0.38) | ALOX12KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL17737480 | 0.76 | FFAR4 (0.46) | SLC40A1FFAR4IDO1KMT2AMEN1 | |
| SCHEMBL18889904 | 0.75 | KMT2A (0.71) | SLC40A1GLO1FFAR4KMT2AMEN1 | |
| SCHEMBL4528495 | 0.74 | KEAP1 (0.65) | GLO1HTTRORCKEAP1 | |
| SCHEMBL27705 | 0.73 | BDKRB1 (0.50) | FFAR4ALDH1A1MAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3215155-B1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD (GB) | 2020-10-14 | — | — | EP | disclosed |
| US-10287252-B2 | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase | IOMET PHARMA LTD. (GB) | 2019-05-14 | — | — | US | disclosed |
| WO-2016071283-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD (GB) | 2016-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287252-B2 | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase | TDO2, IDO2, IDO1 | ALOX12 832/4885SLC40A1 2382/4885GLO1 936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.