Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | CCR9 | P51686 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17737478 | 0.85 | ALDH1A1 (0.52) | CCR9PIK3CASLC40A1IDO1CCR2 | |
| SCHEMBL17737455 | 0.83 | IDO1 (0.55) | FFAR4LMNASLC40A1IDO1MEN1 | |
| SCHEMBL22536974 | 0.78 | CYP3A4 (0.35) | LMNAALDH1A1TP53HTTCHUK | |
| SCHEMBL17737469 | 0.76 | ALOX12 (0.56) | FFAR4LMNASLC40A1IDO1MEN1 | |
| SCHEMBL12161518 | 0.76 | FFAR4 (0.51) | FFAR4CCR9LMNACCR2MEN1 | |
| SCHEMBL19852984 | 0.75 | ALDH1A1 (0.52) | CCR9PIK3CASLC40A1CCR2MEN1 | |
| SCHEMBL10222601 | 0.75 | FFAR4 (0.50) | FFAR4CCR9LMNACCR2MEN1 | |
| SCHEMBL10223642 | 0.75 | FFAR4 (0.43) | FFAR4CCR9LMNACCR2MEN1 | |
| SCHEMBL10223736 | 0.73 | CCR2 (0.58) | FFAR4CCR9LMNACCR2MEN1 | |
| SCHEMBL28063 | 0.73 | CCR2 (0.50) | FFAR4CCR9LMNACCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3215155-B1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD (GB) | 2020-10-14 | — | — | EP | disclosed |
| US-10287252-B2 | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase | IOMET PHARMA LTD. (GB) | 2019-05-14 | — | — | US | disclosed |
| US-20180037553-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD. (GB) | 2018-02-08 | — | — | US | disclosed |
| WO-2016071283-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD (GB) | 2016-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287252-B2 | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase | TDO2, IDO2, IDO1 | FFAR4 2470/4885CCR9 1656/4885LMNA 3562/4885 |
| US-20180037553-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | TDO2, IDO2, IDO1 | FFAR4 2470/4885CCR9 1656/4885LMNA 3562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.