Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.36 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 3/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.32 |
| ▸ | AR | P10275 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL495955 | 0.94 | MEN1 (0.33) | CHEK1RPS6KA3SRPK1PGRNR3C2 | |
| SCHEMBL495857 | 0.92 | MEN1 (0.31) | CHEK1RPS6KA3SRPK1ALDH1A1MEN1 | |
| SCHEMBL495888 | 0.85 | MEN1 (0.41) | PGRNR3C2ARALDH1A1MEN1 | |
| SCHEMBL496465 | 0.85 | MEN1 (0.41) | PGRNR3C2ARALDH1A1MEN1 | |
| SCHEMBL496194 | 0.81 | CHEK1 (0.40) | CHEK1RPS6KA3SRPK1PGRNR3C2 | |
| SCHEMBL496119 | 0.75 | FER (0.39) | CHEK1RPS6KA3SRPK1PGRNR3C2 | |
| SCHEMBL4368419 | 0.73 | FER (0.36) | CHEK1RPS6KA3SRPK1PGRNR3C2 | |
| SCHEMBL14976231 | 0.71 | JAK3 (0.42) | CHEK1RPS6KA3SRPK1 | |
| SCHEMBL17745697 | 0.71 | JAK2 (0.33) | AR | |
| SCHEMBL496442 | 0.71 | FER (0.34) | CHEK1RPS6KA3SRPK1PGRNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106190-B2 | 2-aminobenzamide derivatives | ASTELLAS PHARMA INC. (JP) | 2012-01-31 | — | — | US | disclosed |