Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL177527 | 0.85 | MRGPRX4 (0.42) | IDO1PPARGPPARAPYCR1NOTUM | |
| SCHEMBL3923371 | 0.78 | IDO1 (0.56) | IDO1PPARGPPARAHTR3EHTR3B | |
| SCHEMBL1043138 | 0.78 | MAPT (0.52) | IDO1PPARGPPARAHTR3EHTR3B | |
| SCHEMBL29573736 | 0.78 | MAPT (0.52) | IDO1PPARGPPARAHTR3EHTR3B | |
| SCHEMBL6764202 | 0.76 | IDO1 (0.45) | IDO1PPARGPPARAHTR3EHTR3B | |
| SCHEMBL10709853 | 0.76 | IDO1 (0.45) | IDO1PPARGPPARAHTR3EHTR3B | |
| SCHEMBL177501 | 0.74 | HSP90AA1 (0.47) | PPARGPPARAHSD17B10 | |
| SCHEMBL1231963 | 0.74 | KIF11 (0.43) | — | |
| SCHEMBL17352145 | 0.74 | PPARG (0.46) | IDO1PPARGPPARAHTR3EHTR3B | |
| SCHEMBL22829 | 0.74 | AR (0.43) | CA1CA2CA7CA9AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109280032-B | Pyridazinone mother nucleus structure histone deacetylase inhibitor and preparation method and application thereof | 中国科学院上海药物研究所 | 2023-05-12 | — | — | CN | disclosed |
| US-9415027-B2 | Therapeutic agents | ALLERGAN, INC. (US) | 2016-08-16 | — | — | US | disclosed |
| US-20150344503-A1 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE, METHODS OF TREATMENT AND METHODS OF PREPARING SAME | INFINITY PHARMACEUTICALS INC (US) | 2015-12-03 | — | — | US | disclosed |
| US-20150258048-A1 | THERAPEUTIC AGENTS | ALLERGAN, INC. | 2015-09-17 | — | — | US | disclosed |
| US-9108989-B2 | Inhibitors of fatty acid amide hydrolase | INFINITY PHARMACEUTICALS, INC. (US) | 2015-08-18 | — | — | US | disclosed |
| US-9051294-B2 | Therapeutic agents | ALLERGAN, INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-9006429-B2 | Herbicidal pyrandione, thiopyrandione, and cyclohexanetrione derivatives | SYNGENTA CROP PROTECTION, LLC (US) | 2015-04-14 | — | — | US | disclosed |
| WO-2014179263-A1 | THERAPEUTIC AGENTS | ALLERGAN, INC. (US) | 2014-11-06 | — | — | WO | disclosed |
| US-20140323558-A1 | THERAPEUTIC AGENTS | ALLERGAN, INC. (US) | 2014-10-30 | — | — | US | disclosed |
| EP-2102181-B1 | 4-PHENYL-PYRANE-3,5-DIONES, 4-PHENYL-THIOPYRANE-3,5-DIONES AND CYCLOHEXANETRIONES AS NOVEL HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-06-18 | — | — | EP | disclosed |
| US-20110230440-A1 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE | ADAMS JULIAN | 2011-09-22 | — | — | US | disclosed |
| US-20110224171-A1 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE | INFINITY DISCOVERY, INC. | 2011-09-15 | — | — | US | disclosed |
| EP-2073816-B1 | BORONIC ACIDS AND ESTERS AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE | INFINITY PHARMACEUTICALS INC (US) | 2011-09-14 | — | — | EP | disclosed |
| US-7947663-B2 | Inhibitors of fatty acid amide hydrolase | INFINITY PHARMACEUTICALS, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20100210466-A1 | 4-PHENYL-PYRANE-3,5-DIONES,4-PHENYL-THIOPYRANE-3,6-DIONES AND CYCLOHEXANETRIONES AS NOVEL HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2010-08-19 | — | — | US | disclosed |
| EP-2102181-A1 | 4-PHENYL-PYRANE-3,5-DIONES, 4-PHENYL-THIOPYRANE-3,5-DIONES AND CYCLOHEXANETRIONES AS NOVEL HERBICIDES | Syngeta Participations AG (CH) | 2009-09-23 | — | — | EP | disclosed |
| EP-2073816-A2 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE | Infinity Pharmaceuticals, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| US-20090099131-A1 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE | INFINITY DISCOVERY, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| WO-2008071405-A1 | 4-PHENYL-PYRANE-3,5-DIONES, 4-PHENYL-THIOPYRANE-3,5-DIONES AND CYCLOHEXANETRIONES AS NOVEL HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008063300-A2 | BORONIC ACIDS AND ESTERS AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE | INFINITY PHARMACEUTICALS, INC. (US) | 2008-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210466-A1 | 4-PHENYL-PYRANE-3,5-DIONES,4-PHENYL-THIOPYRANE-3,6-DIONES AND CYCLOHEXANETRIONES AS NOVEL HERBICIDES | DDT, HPD, CYP4B1 | IDO1 1012/4885PPARG 46/4885PPARA 47/4885 |
| US-20110224171-A1 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, ASAH1 | IDO1 201/4885PPARG 567/4885PPARA 633/4885 |
| US-20090099131-A1 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, ASAH1 | IDO1 201/4885PPARG 567/4885PPARA 633/4885 |
| US-20140323558-A1 | THERAPEUTIC AGENTS | PTGER4, PTGER2, PTGER1 | IDO1 2623/4885PPARG 204/4885PPARA 350/4885 |
| US-20150344503-A1 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE, METHODS OF TREATMENT AND METHODS OF PREPARING SAME | FAAH, FAAH2, ASAH1 | IDO1 314/4885PPARG 596/4885PPARA 631/4885 |
| US-20110230440-A1 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, ASAH1 | IDO1 201/4885PPARG 567/4885PPARA 633/4885 |
| US-20150258048-A1 | THERAPEUTIC AGENTS | PTGER4, PTGER2, PTGER1 | IDO1 2623/4885PPARG 204/4885PPARA 350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.