Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994825 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2ALOX15ALDH1A1USP2NPSR1 | |
| SCHEMBL7994828 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2ALOX15ALDH1A1USP2NPSR1 | |
| SCHEMBL68780 | 0.98 | — | — | |
| SCHEMBL61666 | 0.91 | — | — | |
| SCHEMBL7991219 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2ALOX15ALDH1A1USP2NPSR1 | |
| SCHEMBL7991224 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2ALOX15ALDH1A1USP2NPSR1 | |
| SCHEMBL4325752 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2ALOX15ALDH1A1USP2NPSR1 | |
| SCHEMBL2513477 | 0.85 | ALDH1A1 (0.52) | SMN1; SMN2ALOX15ALDH1A1USP2NPSR1 | |
| SCHEMBL4337073 | 0.85 | SMN1; SMN2 (0.42) | SMN1; SMN2ALOX15ALDH1A1USP2NPSR1 | |
| SCHEMBL4337065 | 0.85 | SMN1; SMN2 (0.42) | SMN1; SMN2ALOX15ALDH1A1USP2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105482-A1 | Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2009-04-23 | — | — | US | claimed |
| JP-2009501198-A | — | — | 2009-01-15 | — | — | JP | claimed |
| CN-101263131-A | Urea glucokinase activators | NOVO NORDISK AS (US) | 2008-09-10 | — | — | CN | claimed |
| EP-1904467-A1 | UREA GLUCOKINASE ACTIVATORS | Novo Nordisk A/S (DK) | 2008-04-02 | — | — | EP | claimed |
| WO-2007006814-A1 | UREA GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2007-01-18 | — | — | WO | claimed |
| EP-3638686-B1 | PEPTIDYL KETOAMIDES AS INHIBITORS OF ROHOMBOID PROTEASES | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I (CZ) | 2021-10-27 | — | — | EP | disclosed |
| US-10927146-B2 | Peptidyl ketoamides as inhibitors of rhomboid proteases | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2021-02-23 | — | — | US | disclosed |
| EP-3638686-A1 | PEPTIDYL KETOAMIDES AS INHIBITORS OF ROHOMBOID PROTEASES | Ústav Organické Chemie A Biochemie Akademie Ved Ceské Republiky, v.v.i. (CZ) | 2020-04-22 | — | — | EP | disclosed |
| US-20200095278-A1 | PEPTIDYL KETOAMIDES AS INHIBITORS OF ROHOMBOID PROTEASES | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2020-03-26 | — | — | US | disclosed |
| WO-2018228617-A1 | PEPTIDYL KETOAMIDES AS INHIBITORS OF ROHOMBOID PROTEASES | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2018-12-20 | — | — | WO | disclosed |
| US-8586614-B2 | Urea glucokinase activators | NOVO NORDISK A/S (DK) | 2013-11-19 | — | — | US | disclosed |
| CN-101263131-B | Urea glucokinase activators | TRANSTECH PHARMA INC | 2013-04-24 | — | — | CN | disclosed |
| US-4638071-A | ARTIFICIAL SWEETENERS | GENERAL FOODS CORPORATION (US) | 1987-01-20 | — | — | US | disclosed |
| US-4636396-A | Foodstuff with L-aminodicarboxylic acid gem-diamines | GENERAL FOODS CORPORATION (US) | 1987-01-13 | — | — | US | disclosed |
| US-4622417-A | DIETETICS | GENERAL FOODS CORPORATION (US) | 1986-11-11 | — | — | US | disclosed |
| US-4622418-A | LOW CALORIE SWEETENERS | GENERAL FOODS CORPORATION (US) | 1986-11-11 | — | — | US | disclosed |
| EP-0199258-A2 | L-Aminodicarboxylic acid amides and an edible composition containing same | GENERAL FOODS CORPORATION (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4619782-A | L-aminodicarboxylic acid gem-diamines | GENERAL FOODS CORPORATION (US) | 1986-10-28 | — | — | US | disclosed |
| EP-0186173-A2 | L-Aminodicarboxylic-(0-cycloalkyl)-L-aminocarboxylate alkyl esters, an edible composition containing same as sweeteners and a method for sweetening an edible composition | GENERAL FOODS CORPORATION (US) | 1986-07-02 | — | — | EP | disclosed |
| US-4572799-A | L-Aminodicarboxylic acid amides | GENERAL FOODS CORPORATION (US) | 1986-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927146-B2 | Peptidyl ketoamides as inhibitors of rhomboid proteases | PARL, TMPRSS15, RNASE1 | SMN1; SMN2 2101/4885ALOX15 240/4885ALDH1A1 4168/4885 |
| US-20200095278-A1 | PEPTIDYL KETOAMIDES AS INHIBITORS OF ROHOMBOID PROTEASES | RNASE1, TMPRSS15, SPINT2 | SMN1; SMN2 1331/4885ALOX15 206/4885ALDH1A1 3485/4885 |
| US-20090105482-A1 | Urea Glucokinase Activators | GCK, GCKR, HK2 | SMN1; SMN2 2536/4885ALOX15 4163/4885ALDH1A1 1040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.