Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18641811 | 0.76 | ALOX5 (0.52) | MAPTPKMLMNAL3MBTL1NPC1 | |
| SCHEMBL17769493 | 0.76 | NPC1 (0.36) | MAPTLMNAL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL10519075 | 0.75 | GABRA1 (0.66) | L3MBTL1GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL11022178 | 0.72 | NPC1 (0.43) | MAPTPKMLMNANPC1GABRA1 | |
| SCHEMBL31433701 | 0.71 | KDM5A (0.54) | MAPTPKMLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL20291769 | 0.71 | MAPT (0.63) | MAPTPKMLMNAL3MBTL1GABRA1 | |
| SCHEMBL31433576 | 0.70 | MAPT (0.47) | MAPTPKMLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL17242463 | 0.70 | GABRA1 (0.66) | L3MBTL1GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL7816219 | 0.70 | GAA (0.68) | MAPTLMNAGABRA1GABRB1GABRA3 | |
| SCHEMBL10974102 | 0.69 | NPC1 (0.43) | MAPTPKMLMNAL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221295-A1 | MONOCARBOXYLATE TRANSPORT MODULATORS AND USES THEREOF | Nirogyone Therapeutics, Inc. (US) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016081464-A1 | MONOCARBOXYLATE TRANSPORT MODULATORS AND USES THEREOF | NIROGYONE THERAPEUTICS, INC. (US) | 2016-05-26 | — | — | WO | disclosed |