Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7113113 | 0.76 | ALDH1A1 (0.45) | NPC1MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL4961457 | 0.73 | GABRA1 (0.54) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL17769795 | 0.72 | MAPT (0.46) | NPC1MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL6904411 | 0.72 | KDM4E (0.40) | MAPTALDH1A1KMT2ARXFP1KDM4E | |
| SCHEMBL29354675 | 0.70 | MAPT (0.43) | NPC1MAPTALDH1A1KMT2ARXFP1 | |
| SCHEMBL10974102 | 0.70 | NPC1 (0.43) | NPC1MAPTALDH1A1KMT2ARXFP1 | |
| SCHEMBL5716973 | 0.70 | ALOX5 (0.58) | NPC1RXFP1GABRA1GABRB2 | |
| SCHEMBL7010787 | 0.68 | ALOX5 (0.56) | NPC1MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL6714654 | 0.68 | IDO1 (0.39) | ALDH1A1KDM4E | |
| SCHEMBL1420569 | 0.67 | CYP2D6 (0.47) | MAPTLMNAPKMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153163-A2 | 7-Substituted-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids; 7-substituted-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acids; their derivatives; and a process for preparing the compounds | WARNER-LAMBERT COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |
| EP-0106489-A2 | Antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1984-04-25 | — | — | EP | disclosed |