Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 2/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | CDK3 | Q00526 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754558 | 1.00 | JAK3 (0.36) | JAK3MAPK1ABL1WNT3AUSP30 | |
| SCHEMBL17778897 | 0.89 | WNT3A (0.42) | JAK3MAPK1ABL1WNT3AGSK3B | |
| SCHEMBL17778323 | 0.88 | KARS1 (0.40) | MAPK1ABL1WNT3AGSK3BMTOR | |
| SCHEMBL16754282 | 0.88 | KARS1 (0.40) | MAPK1ABL1WNT3AGSK3BMTOR | |
| SCHEMBL17618509 | 0.87 | WNT3A (0.41) | ABL1WNT3AGSK3B | |
| SCHEMBL19689803 | 0.87 | JAK3 (0.37) | JAK3MAPK1ABL1GSK3BCDK1 | |
| SCHEMBL19706797 | 0.87 | JAK3 (0.37) | JAK3MAPK1ABL1GSK3BCDK1 | |
| SCHEMBL17768095 | 0.87 | ABL1 (0.37) | JAK3MAPK1ABL1WNT3AUSP30 | |
| SCHEMBL17768178 | 0.87 | ABL1 (0.37) | JAK3MAPK1ABL1WNT3AUSP30 | |
| SCHEMBL17778385 | 0.87 | WNT3A (0.40) | ABL1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016081692-A2 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-05-26 | — | — | WO | disclosed |