Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 20/20 | 1.00 |
| ▸ | TPO | P07202 | 16/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30618050 | 1.00 | MPO (1.00) | MPOTPOKCNH2CYP3A4 | |
| SCHEMBL17782030 | 0.85 | MPO (1.00) | MPOTPOKCNH2CYP3A4 | |
| SCHEMBL17782014 | 0.83 | MPO (1.00) | MPOTPOKCNH2CYP3A4 | |
| SCHEMBL17782016 | 0.80 | MPO (1.00) | MPOTPOKCNH2CYP3A4 | |
| SCHEMBL17782051 | 0.80 | MPO (1.00) | MPOTPOKCNH2CYP3A4 | |
| SCHEMBL17782061 | 0.78 | MPO (0.66) | MPOTPOKCNH2CYP3A4 | |
| SCHEMBL17782081 | 0.78 | MPO (0.73) | MPOTPOKCNH2CYP3A4 | |
| SCHEMBL1536690 | 0.76 | MPO (0.69) | MPOTPOKCNH2CYP3A4 | |
| SCHEMBL30749183 | 0.75 | MPO (0.70) | MPOTPOKCNH2CYP3A4 | |
| SCHEMBL27223960 | 0.75 | MPO (0.70) | MPOTPOKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210228585-A1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-d]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | ASTRAZENECA AB (SE) | 2021-07-29 | — | — | US | claimed |
| EP-3227294-B1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | ASTRAZENECA AB (SE) | 2019-08-14 | — | — | EP | claimed |
| EP-3227294-A1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | Astrazeneca AB (SE) | 2017-10-11 | — | — | EP | claimed |
| US-9616063-B2 | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase | ASTRAZENECA AB (SE) | 2017-04-11 | — | — | US | claimed |
| WO-2016087338-A1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | ASTRAZENECA AB (SE) | 2016-06-09 | — | — | WO | claimed |
| US-20160152623-A1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-d]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | ASTRAZENECA AB (SE) | 2016-06-02 | — | — | US | claimed |
| US-12569489-B2 | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase | ASTRAZENECA AB (SE) | 2026-03-10 | — | — | US | disclosed |
| US-20240335446-A1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-d]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | ASTRAZENECA AB (SE) | 2024-10-10 | — | — | US | disclosed |
| US-11975004-B2 | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase | ASTRAZENECA AB (SE) | 2024-05-07 | — | — | US | disclosed |
| EP-3654983-B1 | MPO INHIBITORS FOR USE IN MEDICINE | ASTRAZENECA AB (SE) | 2023-08-30 | — | — | EP | disclosed |
| US-11738027-B2 | MPO inhibitors for use in medicine | ASTRAZENECA AB (SE) | 2023-08-29 | — | — | US | disclosed |
| CN-110891572-B | MPO inhibitors for medical use | 阿斯利康(瑞典)有限公司 | 2023-08-15 | — | — | CN | disclosed |
| US-20220160715-A1 | MPO INHIBITORS FOR USE IN MEDICINE | ASTRAZENECA AB (SE) | 2022-05-26 | — | — | US | disclosed |
| US-20170173025-A1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-d]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | ASTRAZENECA AB (SE) | 2017-06-22 | — | — | US | disclosed |
| US-9616063-B2 | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase | ASTRAZENECA AB (SE) | 2017-04-11 | — | — | US | disclosed |
| US-9616063-B2 | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase | ASTRAZENECA AB (SE) | 2017-04-11 | — | — | US | disclosed |
| WO-2016087338-A1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | ASTRAZENECA AB (SE) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016087338-A1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | ASTRAZENECA AB (SE) | 2016-06-09 | — | — | WO | disclosed |
| US-20160152623-A1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-d]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | ASTRAZENECA AB (SE) | 2016-06-02 | — | — | US | disclosed |
| US-20160152623-A1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-d]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | ASTRAZENECA AB (SE) | 2016-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160152623-A1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-d]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | MPO, GPX1, TH | MPO 1/4885TPO 21/4885KCNH2 2271/4885 |
| US-11738027-B2 | MPO inhibitors for use in medicine | MPO, SERPINB1, MMP8 | MPO 1/4885TPO 23/4885KCNH2 4623/4885 |
| US-20240335446-A1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-d]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | MPO, GPX1, TH | MPO 1/4885TPO 21/4885KCNH2 2271/4885 |
| US-20210228585-A1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-d]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | MPO, GPX1, TH | MPO 1/4885TPO 21/4885KCNH2 2271/4885 |
| US-20170173025-A1 | 1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-d]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE | MPO, GPX1, TH | MPO 1/4885TPO 21/4885KCNH2 2271/4885 |
| US-11975004-B2 | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase | MPO, GPX1, TH | MPO 1/4885TPO 21/4885KCNH2 2271/4885 |
| US-12569489-B2 | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase | MPO, EPX, LPO | MPO 1/4885TPO 4/4885KCNH2 3582/4885 |
| US-20220160715-A1 | MPO INHIBITORS FOR USE IN MEDICINE | MPO, SERPINB1, MMP8 | MPO 1/4885TPO 23/4885KCNH2 4623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.