SCHEMBL17785366

SCHEMBL17785366

COc1ccnc(CNC(=O)OC(C)(C)C)c1F

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 8/20 0.43
ATR Q13535 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
GFER P55789 1/20 0.40
HSD17B10 Q99714 1/20 0.40
AAK1 Q2M2I8 1/20 0.39
DRD2 P14416 1/20 0.39
SSTR4 P31391 1/20 0.39
NAMPT P43490 1/20 0.38
KDM4A O75164 1/20 0.38
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA9 Q16790 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29366380 1.00 KLKB1 (0.43) KLKB1ATRL3MBTL1GFERHSD17B10
SCHEMBL17785326 0.90 KCNH2 (0.40) KLKB1ATRL3MBTL1GFERHSD17B10
SCHEMBL21455353 0.86 ATR (0.44) KLKB1ATRL3MBTL1AAK1SSTR4
SCHEMBL30564617 0.83 L3MBTL1 (0.41) ATRL3MBTL1AAK1SSTR4NAMPT
SCHEMBL31438501 0.83 L3MBTL1 (0.41) ATRL3MBTL1AAK1SSTR4NAMPT
SCHEMBL29023442 0.81 ATR (0.41) ATRL3MBTL1AAK1SSTR4NAMPT
SCHEMBL25198671 0.81 ATR (0.43) ATRL3MBTL1AAK1SSTR4NAMPT
SCHEMBL27033926 0.80 MTNR1A (0.50) KLKB1AAK1SSTR4
SCHEMBL31352678 0.79 SSTR4 (0.44) ATRL3MBTL1SSTR4NAMPTKDM4A
SCHEMBL18764702 0.77 NAMPT (0.46) KLKB1L3MBTL1NAMPTKDM4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4673437-A1 NEW SOLID FORM OF A PLASMA KALLIKREIN INHIBITOR Kalvista Pharmaceuticals Limited (GB) 2026-01-07 EP disclosed
US-20250281397-A1 FORMULATIONS OF A PLASMA KALLIKREIN INHIBITOR KALVISTA PHARMACEUTICALS LIMITED (GB) 2025-09-11 US disclosed
US-20250074903-A1 N-((HET)Arylmethyl)-Heteroaryl-Carboxamides Compounds As Kallikrein Inhibitors DRI UK LP (KY) 2025-03-06 US disclosed
EP-4480545-A2 FORMULATIONS OF A PLASMA KALLIKREIN INHIBITOR Kalvista Pharmaceuticals Limited (GB) 2024-12-25 EP disclosed
WO-2024180100-A1 NEW SOLID FORM OF A PLASMA KALLIKREIN INHIBITOR KALVISTA PHARMACEUTICALS LIMITED (GB) 2024-09-06 WO disclosed
EP-4288036-B1 FORMULATIONS OF A PLASMA KALLIKREIN INHIBITOR KALVISTA PHARMACEUTICALS LTD (GB) 2024-08-07 EP disclosed
US-20240199573-A1 POLYMORPHS OF N-[(3-FLUORO-4-METHOXYPYRIDIN-2-YL)METHYL]-3-(METHOXYMETHYL)-1-({4-[(2-OXOPYRIDIN-1-YL)METHYL]PHENYL}METHYL)PYRAZOLE-4-CARBOXAMIDE AND SALTS THEREOF DRI UK LP (KY) 2024-06-20 US disclosed
CN-118078821-A Treatment of vascular oedema 卡尔维斯塔制药有限公司 2024-05-28 CN disclosed
US-20240122909-A1 TREATMENTS OF HEREDITARY ANGIOEDEMA DRI UK LP (KY) 2024-04-18 US disclosed
EP-4291186-A1 TREATMENTS OF HEREDITARY ANGIOEDEMA Kalvista Pharmaceuticals Limited (GB) 2023-12-20 EP disclosed
US-10364238-B2 N-((het) arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors KALVISTA PHARMACEUTICALS LIMITED (GB) 2019-07-30 US disclosed
US-20190218205-A1 PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS KALVISTA PHARMACEUTICALS LIMITED (GB) 2019-07-18 US disclosed
EP-3224256-B1 N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS, KALVISTA PHARMACEUTICALS LTD (GB) 2019-07-03 EP disclosed
EP-3464271-A1 PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS Kalvista Pharmaceuticals Limited (GB) 2019-04-10 EP disclosed
EP-3464265-A1 POLYMORPHS OF N-[(3-FLUORO-4-METHOXYPYRIDIN-2-YL)METHYL]-3-(METHOXYMETHYL)-1 -({4-[2-OXOPYRIDIN-1 -YL)METHYL]PHENYL} METHYL) PYRAZOLE -4-CARBOXAMIDE AS KALLIKREIN INHIBITORS Kalvista Pharmaceuticals Limited (GB) 2019-04-10 EP disclosed
US-20180319782-A1 N-((HET) ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS DRI UK LP (KY) 2018-11-08 US disclosed
WO-2017207983-A1 PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS KALVISTA PHARMACEUTICALS LIMITED (GB) 2017-12-07 WO disclosed
WO-2017208005-A1 POLYMORPHS OF N-[(3-FLUORO-4-METHOXYPYRIDIN-2-YL)METHYL]-3-(METHOXYMETHYL)-1 -({4-[2-OXOPYRIDIN-1 -YL)METHYL]PHENYL} METHYL) PYRAZOLE -4-CARBOXAMIDE AS KALLIKREIN INHIBITORS KALVISTA PHARMACEUTICALS LIMITED (GB) 2017-12-07 WO disclosed
EP-3224256-A1 N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS, Kalvista Pharmaceuticals Limited (GB) 2017-10-04 EP disclosed
WO-2016083820-A1 N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS, KALVISTA PHARMACEUTICALS LIMITED (GB) 2016-06-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180319782-A1 N-((HET) ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS KLKB1, BDKRB1, BDKRB2 KLKB1 1/4885ATR 4106/4885L3MBTL1 1915/4885
US-20240122909-A1 TREATMENTS OF HEREDITARY ANGIOEDEMA SERPINB1, SERPINH1, SERPINE1 KLKB1 4/4885ATR 4759/4885L3MBTL1 2410/4885
US-20190218205-A1 PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS KLKB1, KLK5, KLK1 KLKB1 1/4885ATR 3419/4885L3MBTL1 1930/4885
US-10364238-B2 N-((het) arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors KLKB1, BDKRB1, BDKRB2 KLKB1 1/4885ATR 4106/4885L3MBTL1 1915/4885
US-20250281397-A1 FORMULATIONS OF A PLASMA KALLIKREIN INHIBITOR KLKB1, KLK5, KLK1 KLKB1 1/4885ATR 3635/4885L3MBTL1 4017/4885
US-20240199573-A1 POLYMORPHS OF N-[(3-FLUORO-4-METHOXYPYRIDIN-2-YL)METHYL]-3-(METHOXYMETHYL)-1-({4-[(2-OXOPYRIDIN-1-YL)METHYL]PHENYL}METHYL)PYRAZOLE-4-CARBOXAMIDE AND SALTS THEREOF CYP3A4, CYP4B1, TPMT KLKB1 4305/4885ATR 3917/4885L3MBTL1 3733/4885
US-20250074903-A1 N-((HET)Arylmethyl)-Heteroaryl-Carboxamides Compounds As Kallikrein Inhibitors KLKB1, BDKRB1, BDKRB2 KLKB1 1/4885ATR 4111/4885L3MBTL1 2037/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.