Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.45 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786046 | 0.83 | PYCR1 (0.45) | PYCR1ALDH1A1AOC3MAOAMAOB | |
| SCHEMBL19327561 | 0.83 | PYCR1 (0.45) | PYCR1ALDH1A1HTTKDM4EMAOB | |
| SCHEMBL1024967 | 0.82 | ALDH1A1 (0.47) | PYCR1ALDH1A1HTTPOLBKMT2A | |
| SCHEMBL15307297 | 0.74 | SLC6A4 (0.40) | PYCR1SLC6A4SLC6A2SLC6A3HTR2A | |
| SCHEMBL5703569 | 0.70 | NR1D1 (0.53) | PYCR1NR1D1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL10294049 | 0.70 | PYCR1 (0.48) | PYCR1SLC6A4SLC6A2SLC6A3HTR2A | |
| SCHEMBL11405433 | 0.67 | ALDH1A1 (0.61) | PYCR1NR1D1SLC6A4ALDH1A1HTT | |
| SCHEMBL22443393 | 0.67 | ALDH1A1 (0.42) | PYCR1ALDH1A1HTTRAB9APOLB | |
| SCHEMBL11575007 | 0.66 | SLC6A4 (0.52) | PYCR1SLC6A4SLC6A2SLC6A3HTR2A | |
| SCHEMBL2823833 | 0.64 | SLC6A4 (0.55) | PYCR1SLC6A4SLC6A2SLC6A3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10829453-B2 | Antagonists of the kappa opioid receptor | UNIVERSITY OF KANSAS (US) | 2020-11-10 | — | — | US | disclosed |
| US-20190300486-A1 | ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2019-10-03 | — | — | US | disclosed |
| US-10118896-B2 | Antagonists of the kappa opioid receptor | UNIVERSITY OF KANSAS (US) | 2018-11-06 | — | — | US | disclosed |
| US-20170260141-A1 | ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2017-09-14 | — | — | US | disclosed |
| WO-2016086149-A1 | ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR | UNIVERSITY OF KANSAS (US) | 2016-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10829453-B2 | Antagonists of the kappa opioid receptor | OPRK1, OPRD1, OPRL1 | PYCR1 2804/4885NR1D1 133/4885SLC6A4 209/4885 |
| US-10118896-B2 | Antagonists of the kappa opioid receptor | OPRK1, OPRD1, OPRL1 | PYCR1 2804/4885NR1D1 133/4885SLC6A4 209/4885 |
| US-20190300486-A1 | ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR | OPRK1, OPRD1, OPRL1 | PYCR1 2804/4885NR1D1 133/4885SLC6A4 209/4885 |
| US-20170260141-A1 | ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR | OPRK1, OPRD1, OPRL1 | PYCR1 2804/4885NR1D1 133/4885SLC6A4 209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.