Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | BCR | P11274 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL743308 | 0.94 | AURKA (0.48) | RXFP1AURKATSHRKMT2AMAPT | |
| SCHEMBL1779700 | 0.89 | AURKA (0.50) | RXFP1AURKAMAPTABL1BCR | |
| SCHEMBL1779328 | 0.89 | RXFP1 (0.44) | RXFP1AURKAFGFR4ABL1BCR | |
| SCHEMBL1780795 | 0.88 | AURKA (0.45) | RXFP1AURKAFGFR4ABL1BCR | |
| SCHEMBL1778129 | 0.88 | AURKA (0.43) | RXFP1AURKAFGFR4ABL1BCR | |
| SCHEMBL1778872 | 0.86 | AURKA (0.46) | RXFP1AURKAFGFR4ABL1BCR | |
| SCHEMBL3875203 | 0.86 | TSHR (0.51) | RXFP1TSHRKMT2AMAPTMEN1 | |
| SCHEMBL1780912 | 0.86 | AURKA (0.49) | RXFP1AURKAABL1BCRKDM4E | |
| SCHEMBL1780888 | 0.86 | RXFP1 (0.46) | RXFP1AURKATSHRKMT2AMAPT | |
| SCHEMBL1779573 | 0.86 | AURKA (0.43) | RXFP1AURKAFGFR4ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |