Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1780795 | 0.90 | AURKA (0.45) | AURKAABL1BCRCYP2C19FGFR4 | |
| SCHEMBL1779700 | 0.89 | AURKA (0.50) | AURKAABL1BCRRXFP1PPARG | |
| SCHEMBL1779328 | 0.88 | RXFP1 (0.44) | AURKAABL1BCRFGFR4TACR3 | |
| SCHEMBL1778129 | 0.88 | AURKA (0.43) | AURKAABL1BCRFGFR4RXFP1 | |
| SCHEMBL3866838 | 0.87 | CYP1A2 (0.42) | CYP1A2ALPLALPIALPGCYP2C9 | |
| SCHEMBL1780888 | 0.86 | RXFP1 (0.46) | AURKAABL1BCRFGFR4RXFP1 | |
| SCHEMBL1779010 | 0.86 | RXFP1 (0.48) | AURKAABL1BCRFGFR4RXFP1 | |
| SCHEMBL1780912 | 0.86 | AURKA (0.49) | AURKAABL1BCRRXFP1PPARG | |
| SCHEMBL1778008 | 0.85 | AURKA (0.49) | AURKAABL1BCRCYP1A2CYP2C19 | |
| SCHEMBL1779104 | 0.85 | AURKA (0.43) | AURKAABL1BCRFGFR4TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |