SCHEMBL177981

SCHEMBL177981

O=C(O)CCC(CN1C(=O)CCC1=O)Sc1ccccn1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
SMN1; SMN2 Q16637 3/20 0.41
HPGD P15428 3/20 0.41
HSD17B10 Q99714 3/20 0.41
KMT2A Q03164 3/20 0.38
MAPT P10636 3/20 0.38
KDM4E B2RXH2 2/20 0.36
ALOX15 P16050 1/20 0.36
MEN1 O00255 2/20 0.35
PKM P14618 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
RECQL P46063 1/20 0.35
NPC1 O15118 1/20 0.35
LMNA P02545 1/20 0.35
RAB9A P51151 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
DRD2 P14416 1/20 0.35
DRD4 P21917 1/20 0.35
DRD3 P35462 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2002799 0.79 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2HPGDHSD17B10KMT2A
SCHEMBL29139348 0.77 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2HPGDHSD17B10KMT2A
SCHEMBL29112231 0.77 HDAC1 (0.33) KMT2AMEN1PKMLMNA
SCHEMBL23235917 0.73 LMNA (0.39) ALDH1A1SMN1; SMN2HPGDHSD17B10KMT2A
SCHEMBL616909 0.73 ALDH1A1 (0.43) ALDH1A1SMN1; SMN2HPGDHSD17B10KMT2A
SCHEMBL179878 0.72 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2HPGDHSD17B10KMT2A
Succinimide SCHEMBL25387343 0.71 SMN1; SMN2 (0.46) ALDH1A1SMN1; SMN2HPGDHSD17B10KMT2A
SCHEMBL21768397 0.70 ALDH1A1 (0.74) ALDH1A1SMN1; SMN2HPGDHSD17B10KMT2A
SCHEMBL1578256 0.69 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2HPGDHSD17B10KMT2A
SCHEMBL23235912 0.69 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2HPGDHSD17B10KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2019 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3404043-B1 ANTI-CDH3 ANTIBODY HAVING HIGH INTERNALIZATION CAPACITY PERSEUS PROTEOMICS INC (JP) 2022-10-26 EP claimed
US-20220257789-A1 ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATES AND RELATED METHODS EXELIXIS, INC. 2022-08-18 US claimed
EP-3994150-A1 ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATES AND RELATED METHODS Iconic Therapeutics, Inc. (US) 2022-05-11 EP claimed
WO-2021003399-A1 ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATES AND RELATED METHODS ICONIC THERAPEUTICS, INC. (US) 2021-01-07 WO claimed
EP-3708586-A1 ANTI-CDH3 ANTIBODY HAVING HIGH INTERNALIZATION CAPACITY Perseus Proteomics Inc. (JP) 2020-09-16 EP claimed
US-20200155701-A1 HERCEPTIN® ADJUVANT THERAPY GENENTECH, INC. (US) 2020-05-21 US claimed
US-20200048362-A1 METHODS OF TREATMENT USING ANTI-ERBB ANTIBODY-MAYTANSINOID CONJUGATES IMMUNOGEN INC (US) 2020-02-13 US claimed
EP-3126383-B1 MODIFIED J-CHAIN IGM BIOSCIENCES AS (DK) 2018-12-19 EP claimed
EP-3404043-A1 ANTI-CDH3 ANTIBODY HAVING HIGH INTERNALIZATION CAPACITY Perseus Proteomics Inc. (JP) 2018-11-21 EP claimed
US-20180236093-A1 HERCEPTIN® ADJUVANT THERAPY GENENTECH INC (US) 2018-08-23 US claimed
WO-2009140242-A1 ANALYSIS OF ANTIBODY DRUG CONJUGATES BY BEAD-BASED AFFINITY CAPTURE AND MASS SPECTROMETRY GENENTECH, INC. (US) 2009-11-19 WO claimed
US-20090286258-A1 ANALYSIS OF ANTIBODY DRUG CONJUGATES BY BEAD-BASED AFFINITY CAPTURE AND MASS SPECTROMETRY GENENTECH, INC. 2009-11-19 US claimed
US-20080226659-A1 Cancer treatment IMMUNOGEN, INC. 2008-09-18 US claimed
EP-1740954-A1 MASS SPECTROMETRY OF ANTIBODY CONJUGATES Kadkhodayan, Miryam (US) 2007-01-10 EP claimed
US-7097840-B2 Methods of treatment using anti-ErbB antibody-maytansinoid conjugates GENENTECH, INC. (US) 2006-08-29 US claimed
WO-2005101017-A1 MASS SPECTROMETRY OF ANTIBODY CONJUGATES GENENTECH, INC. (US) 2005-10-27 WO claimed
JP-2003503365-A 2003-01-28 JP claimed
EP-1191944-A2 METHODS OF TREATMENT USING ANTI-ErbB ANTIBODY-MAYTANSINOID CONJUGATES Genentech, Inc. (US) 2002-04-03 EP claimed
US-20020001587-A1 Tyrosine kinases; cell differentiation; epidermal growth factor receptor; antitumor agents IMMUNOGEN, INC. 2002-01-03 US claimed
WO-2001000244-A2 METHODS OF TREATMENT USING ANTI-ErbB ANTIBODY-MAYTANSINOID CONJUGATES GENENTECH, INC. (US) 2001-01-04 WO claimed