Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR1E | P28566 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL23883385 | 0.90 | STING1 (0.45) | HTR1AADRA2AADRA2BADRA2CSLC6A2 | |
| SCHEMBL22299626 | 0.83 | CYP2A6 (0.49) | HTR2AMEN1MAPTKMT2AGPR84 | |
| SCHEMBL701071 | 0.80 | GPR84 (0.47) | HTR1AHTR1DHTR2AHTR2CHTR6 | |
| SCHEMBL11005684 | 0.80 | CYP3A4 (0.44) | HTR1DHTR2AHTR2CHTR6ALDH1A1 | |
| SCHEMBL28743536 | 0.77 | IMPDH2 (0.44) | HTR1AADRA2AADRA2BADRA2CSLC6A2 | |
| SCHEMBL1260955 | 0.77 | HTR2A (0.51) | HTR1AHTR2AHTR6ALDH1A1HTT | |
| SCHEMBL30753171 | 0.77 | HTR2A (0.51) | HTR1AHTR2AHTR6ALDH1A1HTT | |
| SCHEMBL8027363 | 0.76 | ALDH1A1 (0.44) | HTR1AADRA2AADRA2BADRA2CSLC6A2 | |
| SCHEMBL2278702 | 0.74 | KDR (0.52) | SLC6A2LMNAHSD17B10MEN1MAPT | |
| SCHEMBL7507194 | 0.74 | HTR2A (0.49) | HTR1AHTR2AALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1088912-A | The 4-amino-3-hydroxycarboxylic acid derivatives | SANDOZ LTD (CH) | 1994-07-06 | — | — | CN | claimed |
| JP-7267913-A | — | — | None | — | — | JP | disclosed |
| CN-109311876-B | Heteroaryl estrogen receptor modulators and uses thereof | 豪夫迈·罗氏有限公司 | 2022-05-03 | — | — | CN | disclosed |
| US-9636341-B2 | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2017-05-02 | — | — | US | disclosed |
| US-20150342950-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-03 | — | — | US | disclosed |
| US-9150543-B2 | Substituted indolyl alkyl amino derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N. V. (BE) | 2015-10-06 | — | — | US | disclosed |
| EP-1755581-B1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MYOCARDIAL CONDITIONS | NORTHERN SYDNEY LOCAL HEALTH DISTR (AU) | 2015-07-15 | — | — | EP | disclosed |
| US-20140309248-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2014-10-16 | — | — | US | disclosed |
| EP-2776462-A1 | INDOLEALKYLAMINO-WITHASTEROID CONJUGATES AND METHOD OF USE | Natreon, Inc. (US) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013070619-A8 | INDOLEALKYLAMINO-WITHASTEROID CONJUGATES AND METHOD OF USE | NATREON, INC. (US) | 2014-05-08 | — | — | WO | disclosed |
| EP-0464558-B1 | Antimigraine alkoxypyrimidine derivatives | BRISTOL MYERS SQUIBB CO (US) | 1994-12-28 | — | — | EP | disclosed |
| CN-1088912-A | The 4-amino-3-hydroxycarboxylic acid derivatives | SANDOZ LTD (CH) | 1994-07-06 | — | — | CN | disclosed |
| US-5300506-A | Indole-3-alkyl derivatives of alkoxypyrimidinylpiperazines | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-04-05 | — | — | US | disclosed |
| EP-0548813-A1 | Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines | Bristol-Myers Squibb Company (US) | 1993-06-30 | — | — | EP | disclosed |
| EP-0464558-A1 | Antimigraine alkoxypyrimidine derivatives | Bristol-Myers Squibb Company (US) | 1992-01-08 | — | — | EP | disclosed |
| US-4495352-A | HYPOTENSIVE AGENTS; VASODILATION; ADRENERGIC BLOCKING ACTION | MEAD JOHNSON & COMPANY (US) | 1985-01-22 | — | — | US | disclosed |
| US-4314943-A | ANTIHYPERTENSIVE AGENTS; VASODILATORS | MEAD JOHNSON & COMPANY (US) | 1982-02-09 | — | — | US | disclosed |
| US-4234595-A | HYPOTENSIVE AGENTS; ADRENERGIC BLOCKING AGENTS; VASODILATION | MEAD JOHNSON & COMPANY (US) | 1980-11-18 | — | — | US | disclosed |
| US-4110322-A | SENILITY, MENTAL PERFORMANCE STIMULANTS | AKZONA INCORPORATED (US) | 1978-08-29 | — | — | US | disclosed |
| US-3997539-A | HYPOTENSIVE, TRANQUILIZER | AMERICAN HOECHST CORPORATION (US) | 1976-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309248-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | HTR1A 578/4885ADRA2A 1734/4885ADRA2B 1830/4885 |
| US-20150342950-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | HTR1A 688/4885ADRA2A 2113/4885ADRA2B 2126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.