SCHEMBL17809490

SCHEMBL17809490

Cc1cc(C(C)(F)F)on1

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.38
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
HSP90AA1 P07900 1/20 0.32
HSP90AB1 P08238 1/20 0.32
CNR2 P34972 1/20 0.32
DRD2 P14416 1/20 0.32
DRD3 P35462 1/20 0.32
CHRNB2 P17787 2/20 0.32
CHRNA4 P43681 2/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
POLB P06746 1/20 0.31
ALDH1A1 P00352 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15473290 0.86 HCAR2 (0.38) HCAR2MEN1KMT2AHSP90AA1HSP90AB1
SCHEMBL9911981 0.84 HCAR2 (0.39) HCAR2MEN1KMT2AHSP90AA1HSP90AB1
SCHEMBL12650126 0.83 HCAR2 (0.35) HCAR2MEN1KMT2AHSP90AA1HSP90AB1
SCHEMBL171117 0.81 KMT2A (0.48) HCAR2MEN1KMT2ACHRNB2CHRNA4
SCHEMBL16996976 0.80 HCAR2 (0.36) HCAR2MEN1KMT2AHSP90AA1HSP90AB1
SCHEMBL9868320 0.77 HCAR2 (0.42) HCAR2MEN1KMT2ACNR2POLB
SCHEMBL20320520 0.77 HCAR2 (0.38) HCAR2MEN1KMT2ACNR2CHRNB2
SCHEMBL2585198 0.77 HCAR2 (0.38) HCAR2MEN1KMT2ACNR2CHRNB2
SCHEMBL2585201 0.77 HCAR2 (0.38) HCAR2MEN1KMT2ACNR2CHRNB2
SCHEMBL10072176 0.77 MLYCD (0.39) HCAR2POLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10744155-B2 Inhibitors of ADAMTS4 or ADAMTS5 for use in preventing or treating cardiac remodeling and chronic heart failure UNIVERSITETET I OSLO (NO) 2020-08-18 US disclosed
US-20190282606-A1 INHIBITORS OF ADAMTS4 OR ADAMTS5 FOR USE IN PREVENTING OR TREATING CARDIAC REMODELING AND CHRONIC HEART FAILURE UNIVERSITETET I OSLO (NO) 2019-09-19 US disclosed
US-10322143-B2 Inhibitors of ADAMTS4 or ADAMTS5 for use in preventing or treating cardiac remodeling and chronic heart failure UNIVERSITETET I OSLO (NO) 2019-06-18 US disclosed
US-20160158271-A1 INHIBITORS OF ADAMTS4 OR ADAMTS5 FOR USE IN PREVENTING OR TREATING CARDIAC REMODELING AND CHRONIC HEART FAILURE UNIVERSITETET I OSLO (NO) 2016-06-09 US disclosed
US-20160158271-A1 INHIBITORS OF ADAMTS4 OR ADAMTS5 FOR USE IN PREVENTING OR TREATING CARDIAC REMODELING AND CHRONIC HEART FAILURE UNIVERSITETET I OSLO (NO) 2016-06-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10322143-B2 Inhibitors of ADAMTS4 or ADAMTS5 for use in preventing or treating cardiac remodeling and chronic heart failure ADAMTS5, ADAMTS4, ADAMTS1 HCAR2 1229/4885MEN1 3006/4885KMT2A 2260/4885
US-20190282606-A1 INHIBITORS OF ADAMTS4 OR ADAMTS5 FOR USE IN PREVENTING OR TREATING CARDIAC REMODELING AND CHRONIC HEART FAILURE ADAMTS5, ADAMTS4, ADAMTS1 HCAR2 1229/4885MEN1 3006/4885KMT2A 2260/4885
US-20160158271-A1 INHIBITORS OF ADAMTS4 OR ADAMTS5 FOR USE IN PREVENTING OR TREATING CARDIAC REMODELING AND CHRONIC HEART FAILURE ADAMTS5, ADAMTS4, ADAMTS1 HCAR2 1229/4885MEN1 3006/4885KMT2A 2260/4885
US-10744155-B2 Inhibitors of ADAMTS4 or ADAMTS5 for use in preventing or treating cardiac remodeling and chronic heart failure ADAMTS5, ADAMTS4, ADAMTS1 HCAR2 1229/4885MEN1 3006/4885KMT2A 2260/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.