Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17811547 | 0.81 | SMN1; SMN2 (0.37) | PGRHTR1AADRA2AADORA3AR | |
| SCHEMBL14718130 | 0.75 | RECQL (0.31) | ALDH1A1SMN1; SMN2KDM4EHPGDRAB9A | |
| SCHEMBL13337266 | 0.70 | AKT2 (0.46) | ALDH1A1SMN1; SMN2KDM4EHPGDRXFP1 | |
| SCHEMBL7661269 | 0.69 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KDM4EHPGDRXFP1 | |
| SCHEMBL2153093 | 0.69 | MAPT (0.39) | PGRHTR1AADRA2AADORA3AR | |
| SCHEMBL14719196 | 0.68 | PTP4A3 (0.48) | ALDH1A1SMN1; SMN2KDM4EHPGDRAB9A | |
| SCHEMBL10109209 | 0.63 | ALOX5 (0.42) | ALDH1A1SMN1; SMN2KDM4EHPGDRAB9A | |
| SCHEMBL12589711 | 0.63 | TDP2 (0.42) | ALDH1A1SMN1; SMN2HPGDRAB9ATDP2 | |
| SCHEMBL13093559 | 0.61 | CHEK1 (0.42) | ALDH1A1SMN1; SMN2KDM4EHPGDRXFP1 | |
| Biphenyl SCHEMBL1855900 | 0.61 | TDP2 (0.52) | PGRALDH1A1SMN1; SMN2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365584-B2 | Thieno [2,3-B] pyridinedione activators of AMPK and therapeutic uses thereof | POXEL (FR) | 2016-06-14 | — | — | US | disclosed |