Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GRM6 | O15303 | 5/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.35 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17811546 | 0.81 | PGR (0.40) | SMN1; SMN2RAB9APGRHTR1AADRA2A | |
| SCHEMBL14718130 | 0.74 | RECQL (0.31) | SMN1; SMN2RAB9AALDH1A1HPGDGAA | |
| SCHEMBL16996824 | 0.69 | GRM6 (0.52) | RAB9AALDH1A1GRM6ALOX5GRM5 | |
| SCHEMBL14190044 | 0.67 | GRM6 (0.50) | RAB9AALDH1A1GRM6ALOX5GRM5 | |
| SCHEMBL14719196 | 0.67 | PTP4A3 (0.48) | SMN1; SMN2RAB9AALDH1A1TDP2CHEK1 | |
| SCHEMBL14897949 | 0.67 | RECQL (0.41) | SMN1; SMN2RAB9AALDH1A1GRM6ALOX5 | |
| SCHEMBL12589711 | 0.65 | TDP2 (0.42) | SMN1; SMN2RAB9AALDH1A1GRIA1CACNG8 | |
| SCHEMBL13713793 | 0.64 | GRM6 (0.47) | SMN1; SMN2RAB9AALDH1A1GRM6ALOX5 | |
| SCHEMBL1821923 | 0.63 | ACHE (0.37) | ALDH1A1GRM6ALOX5GRM5LIMK1 | |
| Biphenyl SCHEMBL1855900 | 0.60 | TDP2 (0.52) | SMN1; SMN2RAB9APGRALDH1A1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365584-B2 | Thieno [2,3-B] pyridinedione activators of AMPK and therapeutic uses thereof | POXEL (FR) | 2016-06-14 | — | — | US | disclosed |