Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998478 | 0.78 | CA1 (0.36) | CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL3844781 | 0.76 | CA1 (0.35) | CA1CA2CA9 | |
| Bromide SCHEMBL20984788 | 0.76 | CA1 (0.35) | CA1CA2CA9 | |
| SCHEMBL4129959 | 0.74 | KIF11 (0.41) | CA1CA2CA9 | |
| SCHEMBL1785242 | 0.72 | HSD17B10 (0.32) | CA1CA2CA9 | |
| SCHEMBL8042966 | 0.71 | CA1 (0.35) | RAPGEF4CA1CA2CA9 | |
| SCHEMBL11568441 | 0.70 | ALDH3A1 (0.31) | RAPGEF4 | |
| SCHEMBL172019 | 0.69 | CA1 (0.35) | RAPGEF4CA1CA2 | |
| SCHEMBL4895474 | 0.69 | ALDH1A1 (0.33) | RAPGEF4CA1CA2 | |
| Phosphoric Acid SCHEMBL20984795 | 0.68 | CA1 (0.34) | CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | MKI67, CYP11B1, IGF1R | DHFR 24/4885RAPGEF4 4203/4885CA1 4000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.