SCHEMBL998478

SCHEMBL998478

NNc1cc(F)c(F)c(F)c1F

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.36
CA2 P00918 2/20 0.36
CA9 Q16790 1/20 0.36
CA12 O43570 1/20 0.31
CA7 P43166 1/20 0.31
CA13 Q8N1Q1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3844781 0.97 CA1 (0.35) CA1CA2CA9CA12CA7
Bromide SCHEMBL20984788 0.97 CA1 (0.35) CA1CA2CA9CA12CA7
Phosphoric Acid SCHEMBL20984795 0.87 CA1 (0.34) CA1CA2CA9
Oxalic Acid SCHEMBL20984318 0.87 CES2 (0.35) CA1CA2CA9CA12
Sulfuric Acid SCHEMBL20984822 0.87 CA1 (0.42) CA1CA2CA9CA12CA7
Nitric Acid SCHEMBL20985006 0.84 CA1 (0.36) CA1CA2CA9CA12
SCHEMBL1781432 0.78 DHFR (0.37) CA1CA2CA9
SCHEMBL24455459 0.77 CES2 (0.38) CA1CA2CA9CA12CA7
SCHEMBL1556479 0.76
Bromide SCHEMBL20984571 0.75 CES2 (0.37) CA1CA2CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11572475-B2 Carbocyanines for G-quadruplex DNA stabilization and telomerase inhibition GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2023-02-07 US disclosed
US-11040938-B2 Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts SHANGHAI HYBRID-CHEM TECHNOLOGIES (CN) 2021-06-22 US disclosed
US-20190152896-A1 Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts SHANGHAI HYBRID-CHEM TECHNOLOGIES (CN) 2019-05-23 US disclosed
CN-107663161-A A kind of continuous stream synthesis technique of phenylhydrazine salt and substituted benzene hydrazonium salt 上海惠和化德生物科技有限公司 2018-02-06 CN disclosed
US-20140142147-A1 Carbocyanines for G-Quadruplex DNA Stabilization and Telomerase Inhibition GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION (US) 2014-05-22 US disclosed
US-20140142147-A1 Carbocyanines for G-Quadruplex DNA Stabilization and Telomerase Inhibition GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION (US) 2014-05-22 US disclosed
WO-2013012886-A1 CARBOCYANINES FOR G-QUADRUPLEX DNA STABILIZATION AND TELOMERASE INHIBITION GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2013-01-24 WO disclosed
EP-1874871-B1 WATER SOLUBLE FLUORO-SUBSTITUTED CYANINE DYES AS REACTIVE FLUORESCENCE LABELLING REAGENTS GE HEALTHCARE UK LTD (GB) 2012-10-03 EP disclosed
EP-2270106-A2 Indolium compounds containing fluoro-substituents GE Healthcare UK Limited (GB) 2011-01-05 EP disclosed
US-20100249385-A1 WATER-SOLUBLE FLUORO-SUBSTITUTED CYANINE DYES AS REACTIVE FLUORESCENCE LABELLING REAGENTS GE HEALTHCARE UK LIMITED (GB) 2010-09-30 US disclosed
US-7767829-B2 Water-soluble fluoro-substituted cyanine dyes as reactive fluorescence labelling reagents GE HEALTHCARE UK LIMITED (GB) 2010-08-03 US disclosed
EP-1874871-A1 WATER SOLUBLE FLUORO-SUBSTITUTED CYANINE DYES AS REACTIVE FLUORESCENCE LABELLING REAGENTS GE Healthcare UK Limited (GB) 2008-01-09 EP disclosed
US-20060239922-A1 WATER-SOLUBLE FLUORO-SUBSTITUTED CYANINE DYES AS REACTIVE FLUORESCENCE LABELLING REAGENTS GE HEALTHCARE UK LIMITED (GB) 2006-10-26 US disclosed
WO-2006111726-A1 WATER SOLUBLE FLUORO-SUBSTITUTED CYANINE DYES AS REACTIVE FLUORESCENCE LABELLING REAGENTS GE HEALTHCARE UK LIMITED (GB) 2006-10-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060239922-A1 WATER-SOLUBLE FLUORO-SUBSTITUTED CYANINE DYES AS REACTIVE FLUORESCENCE LABELLING REAGENTS TPD52L2, MRPL21, MRPL9 CA1 1035/4885CA2 1581/4885CA9 860/4885
US-11572475-B2 Carbocyanines for G-quadruplex DNA stabilization and telomerase inhibition POT1, TERT, TERF2 CA1 3497/4885CA2 1519/4885CA9 1191/4885
US-11040938-B2 Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts HPD, TYR, PDK2 CA1 1443/4885CA2 931/4885CA9 1566/4885
US-20100249385-A1 WATER-SOLUBLE FLUORO-SUBSTITUTED CYANINE DYES AS REACTIVE FLUORESCENCE LABELLING REAGENTS TPD52L2, MRPL9, MRPL21 CA1 1061/4885CA2 1597/4885CA9 666/4885
US-20190152896-A1 Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts HPD, TYR, PDK2 CA1 1443/4885CA2 931/4885CA9 1566/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.