Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1055249 | 0.85 | KIF11 (0.41) | KIF11ALDH1A1GAAHTTHDAC1 | |
| SCHEMBL30682783 | 0.74 | KIF11 (0.51) | KIF11ALDH1A1GAAHTTMAPT | |
| SCHEMBL1781432 | 0.74 | DHFR (0.37) | CA1CA2CA9 | |
| SCHEMBL13831 | 0.74 | KIF11 (0.51) | KIF11ALDH1A1GAAHTTMAPT | |
| SCHEMBL23832033 | 0.74 | KIF11 (0.39) | KIF11ALDH1A1HTTMAPTGFER | |
| SCHEMBL23577416 | 0.71 | KDM4E (0.50) | KIF11ALDH1A1GAAHTTMAPT | |
| SCHEMBL3694279 | 0.71 | DGAT1 (0.41) | HTTHDAC1HDAC6LMNACA1 | |
| SCHEMBL30480929 | 0.71 | ALDH1A1 (0.56) | KIF11ALDH1A1GAAHTTPOLB | |
| SCHEMBL5325638 | 0.71 | ALDH1A1 (0.56) | KIF11ALDH1A1GAAHTTPOLB | |
| SCHEMBL1426650 | 0.70 | RAB9A (0.57) | ALDH1A1MAPTLMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069341-A1 | INHIBITORS OF HSP90 | CHENE PATRICK | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069341-A1 | INHIBITORS OF HSP90 | HSP90AB1, HSP90B1, HSP90AA1 | KIF11 1953/4885ALDH1A1 2811/4885GAA 224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.