Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 10/20 | 0.54 |
| ▸ | RORC | P51449 | 2/20 | 0.49 |
| ▸ | MYC | P01106 | 1/20 | 0.48 |
| ▸ | WDR5 | P61964 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257613 | 0.92 | RORB (0.52) | RORBRORCMYCWDR5ALDH1A1 | |
| SCHEMBL257394 | 0.89 | RORB (0.61) | RORBRORCMYCWDR5CCNA2 | |
| SCHEMBL30395217 | 0.87 | MYC (0.51) | RORBRORCMYCWDR5ALDH1A1 | |
| SCHEMBL11274884 | 0.87 | MYC (0.51) | RORBRORCMYCWDR5ALDH1A1 | |
| SCHEMBL257203 | 0.86 | RORB (0.67) | RORBRORCMYCWDR5ALDH1A1 | |
| SCHEMBL2489836 | 0.84 | MYC (0.51) | RORBRORCMYCWDR5CDK2 | |
| SCHEMBL165773 | 0.81 | ADORA3 (0.61) | RORBALDH1A1MAPTGAAHTT | |
| SCHEMBL178218 | 0.81 | ADORA3 (0.60) | RORBRORCALDH1A1MAPTHTT | |
| SCHEMBL29058658 | 0.80 | CDC7 (0.49) | RORBRORCMYCWDR5ALDH1A1 | |
| SCHEMBL257616 | 0.78 | ADORA3 (0.64) | RORBALDH1A1MAPTMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027965-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012027965-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |