Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | INPP5D | Q92835 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CDC25A | P30304 | 8/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5406429 | 0.87 | INPP5D (0.47) | PTPN1GPBAR1EPHA2AKR1B10AKR1B1 | |
| SCHEMBL3225451 | 0.86 | CDC25A (0.41) | PTPN1GPBAR1EPHA2AKR1B10AKR1B1 | |
| SCHEMBL16226138 | 0.85 | USP2 (0.59) | PTPN1GPBAR1EPHA2AKR1B10AKR1B1 | |
| SCHEMBL15536784 | 0.84 | VDR (0.48) | INPP5DCDC25ACDC25B | |
| SCHEMBL6706039 | 0.84 | CDC25A (0.49) | PTPN1GPBAR1EPHA2AKR1B10AKR1B1 | |
| SCHEMBL15536787 | 0.84 | VDR (0.48) | INPP5DCDC25ACDC25B | |
| SCHEMBL3225968 | 0.80 | PTPN1 (0.46) | PTPN1GPBAR1EPHA2AKR1B10AKR1B1 | |
| SCHEMBL25711251 | 0.75 | USP2 (0.56) | PTPN1GPBAR1EPHA2AKR1B10AKR1B1 | |
| SCHEMBL7623866 | 0.75 | GPBAR1 (0.70) | PTPN1GPBAR1EPHA2AKR1B10AKR1B1 | |
| SCHEMBL14677573 | 0.75 | GPBAR1 (0.70) | PTPN1GPBAR1EPHA2AKR1B10AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230259-B1 | ANTI-FUNGALS TARGETING THE SYNTHESIS OF FUNGAL SHINGOLIPIDS | UNIV NEW YORK STATE RES FOUND (US) | 2024-04-03 | — | — | EP | disclosed |
| US-11390580-B2 | Anti-fungals targeting the synthesis of fungal shingolipids | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2022-07-19 | — | — | US | disclosed |
| US-20200062698-A1 | ANTI-FUNGALS TARGETING THE SYNTHESIS OF FUNGAL SHINGOLIPIDS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-02-27 | — | — | US | disclosed |
| US-20180141897-A1 | ANTI-FUNGALS TARGETING THE SYNTHESIS OF FUNGAL SHINGOLIPIDS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2018-05-24 | — | — | US | disclosed |
| EP-3230259-A1 | ANTI-FUNGALS TARGETING THE SYNTHESIS OF FUNGAL SHINGOLIPIDS | The Research Foundation for The State University of New York (US) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016094307-A1 | ANTI-FUNGALS TARGETING THE SYNTHESIS OF FUNGAL SHINGOLIPIDS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2016-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11390580-B2 | Anti-fungals targeting the synthesis of fungal shingolipids | LSS, ERG28, CYP51A1 | PTPN1 3073/4885GPBAR1 4216/4885EPHA2 2449/4885 |
| US-20180141897-A1 | ANTI-FUNGALS TARGETING THE SYNTHESIS OF FUNGAL SHINGOLIPIDS | LSS, ERG28, CYP51A1 | PTPN1 3073/4885GPBAR1 4216/4885EPHA2 2449/4885 |
| US-20200062698-A1 | ANTI-FUNGALS TARGETING THE SYNTHESIS OF FUNGAL SHINGOLIPIDS | LSS, ERG28, CYP51A1 | PTPN1 3073/4885GPBAR1 4216/4885EPHA2 2449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.