Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.60 |
| ▸ | IDO1 | P14902 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | TTK | P33981 | 2/20 | 0.59 |
| ▸ | ALPL | P05186 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.59 |
| ▸ | TDO2 | P48775 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.55 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12318476 | 0.87 | IDO1 (0.58) | AURKAPDPK1IDO1KDM4EALDH1A1 | |
| SCHEMBL17829604 | 0.84 | MAP2K4 (0.66) | PIM1MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL2466587 | 0.82 | PIM1 (0.56) | AURKAPDPK1TDO2PIM1MAP2K4 | |
| SCHEMBL1513026 | 0.82 | IDO1 (0.65) | AURKAPDPK1IDO1KDM4EALDH1A1 | |
| SCHEMBL699881 | 0.81 | PIM1 (0.52) | AURKAPDPK1IDO1KDM4ETDO2 | |
| SCHEMBL17829688 | 0.80 | PDPK1 (0.57) | PDPK1IDO1KDM4ETDO2PIM1 | |
| SCHEMBL5377653 | 0.79 | MAP2K4 (0.73) | PDPK1IDO1KDM4EALDH1A1TTK | |
| SCHEMBL1513065 | 0.79 | MAP2K4 (0.70) | IDO1KDM4EALDH1A1TTKALPL | |
| SCHEMBL2865013 | 0.79 | LRRK2 (0.57) | PDPK1TDO2PIM1MAP2K4MAPK1 | |
| SCHEMBL2860957 | 0.79 | AURKA (0.66) | AURKAIDO1KDM4EALDH1A1TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160168140-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | SYNERECA PHARMACEUTICALS (US) | 2016-06-16 | — | — | US | disclosed |
| US-20160168140-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | SYNERECA PHARMACEUTICALS (US) | 2016-06-16 | — | — | US | disclosed |
| WO-2016094730-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | SYNERECA PHARMACEUTICALS, INC. (US) | 2016-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168140-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | FOS, FOSB, YAP1 | AURKA 3063/4885PDPK1 1349/4885IDO1 4129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.